2. PROTAC MAPK/ERK Pathway GPCR/G Protein
  3. Molecular Glues Ras Ligands for E3 Ligase
  4. IPS-06061

IPS-06061 is an orally active molecular glue forming a ternary complex of CRBN-KRASG12D-IPS06061, degrading KRASG12D with a DC50 value lower than 500 nM. IPS-06061 shows a strong anti-tumor efficacy.

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IPS-06061

IPS-06061 화학구조

CAS No. : 3064065-83-1

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IPS-06061 Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41

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제품 설명

IPS-06061 is an orally active molecular glue forming a ternary complex of CRBN-KRASG12D-IPS06061, degrading KRASG12D with a DC50 value lower than 500 nM. IPS-06061 shows a strong anti-tumor efficacy[1][2].

IC50 & Target[2]

KRas G12D

<500 nM (DC50)

Cereblon

 

In Vivo

IPS-06061 shows a strong anti-tumor efficacy using a xenograftanimal model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

339.43

화학식

C21H25NO3
CAS No.
SMILES

O=C(OCC)[C@@H](N[C@H](C(C1=CC=CC=C1)=O)C)CCC2=CC=CC=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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IPS-06061 Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IPS-060613064065-83-1IPS06061IPS 06061Molecular GluesRasLigands for E3 LigaseE3 ligase-recruiting Moietynon-small cell lung cancerpancreatic ductal adenocarcinomaKRAS G12D-mutant cancerxenograft animal modelsKRAS G12Dcolorectal cancerCRBNInhibitorinhibitorinhibit

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상품명:
IPS-06061
Cat. No.:
HY-170428
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