PADI3 - peptidyl arginine deiminase 3 Gene

Also Known as PAD3; PDI3; UHS1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51702

About PADI3

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,249,098-17,284,233 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 233 orthologues, 4 paralogues and is associated with 2 phenotypes. Biased expression in urinary bladder (RPKM 6.9) and esophagus (RPKM 2.4).

Summary

This gene encodes a member of the peptidyl arginine deiminase family of Enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four Other paralogous genes. [provided by RefSeq, Jul 2008]

PADI3 Products (1)

mRNA	Protein	Name
NM_016233.2	NP_057317.2	protein-arginine deiminase type-3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein-arginine deiminase activity	IMP IMP: Inferred from mutant phenotype	27866708	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	27866708	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PADI3 Protein Structure

PAD_N

PAD_M

PAD

0
200
400
600
664 a.a.

Protein Preferred Names	Protein Names
protein-arginine deiminase type-3	peptidyl arginine deiminase, type III

PADI3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PADI3	Q9ULW8	ATP5PB	Homo sapiens	P24539	Y2H Array	32814053
Intra	PADI3	Q9ULW8	ATP5PB	Homo sapiens	P24539	Y2H Pooling	32814053
Intra	PADI3	Q9ULW8	ATP5PB	Homo sapiens	P24539	Validated Y2H	32814053
Intra	PADI3	Q9ULW8	MAPK3	Homo sapiens	P27361	Y2H Array	32814053
Intra	PADI3	Q9ULW8	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	PADI3	Q9ULW8	PADI3	Homo sapiens	Q9ULW8	Y2H Prey Pooling	32296183
Intra	PADI3	Q9ULW8	PADI3	Homo sapiens	Q9ULW8	Validated Y2H	32296183
Intra	PADI3	Q9ULW8	PADI3	Homo sapiens	Q9ULW8	Y2H Array	25416956
Intra	PADI3	Q9ULW8	MAPK3	Homo sapiens	P27361	Validated Y2H	32814053
Intra	PADI3	Q9ULW8	MAPK3	Homo sapiens	P27361	Y2H Pooling	32814053
Intra	PADI3	Q9ULW8	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	PADI3	Q9ULW8	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	PADI3	Q9ULW8	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	PADI3	Q9ULW8	PADI3	Homo sapiens	Q9ULW8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Uncombable Hair Syndrome 1	Uncombable Hair Syndrome Pili Trianguli Et Canaliculi Uhs Cheveux Incoiffables Spun Glass Hair Unmanageable Hair Syndrome UHS1 Chevelure En Vadrouille
Central Centrifugal Cicatricial Alopecia	CCCA Central Centrifugal Alopecia
Loose Anagen Hair Syndrome	Loose Anagen Syndrome LAHS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09962	PADI3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21009	Padi3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27526	Padi3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PADI3	VGNC	VGNC:106465
Canis familiaris	PADI3	VGNC	VGNC:44236
Bos taurus	PADI3	VGNC	VGNC:32547
Mus musculus	PADI3	MGD	MGI:1338891
Rattus norvegicus	PADI3	RGD	RGD:3289
Felis catus	PADI3	VGNC	VGNC:80297
Others	PADI3	NCBI