MMK1 TFA
Based on 1 publication(s) in Google Scholar
MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity.
For research use only. We do not sell to patients.
- Formula: C75H123N19O18S.xC2HF3O2
- Molecular Weight:1610.96 (free acid)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MMK1 TFA
MoreAll Calcium Channel Isoforms
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Biological Activity
Description
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Calcium Channel |
In Vitro
MMK-1 TFA induces calcium mobilization in human FPRL1-transfected HEK 293 (FPRL1/293) cells with an EC50 of 2 nM[1].
MMK1 (1 μM; for 4 h) TFA induces selective migration of FPR2-expressing RBL-2H3 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Four-week-old male ddY mice[4]
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Dosage:10, 100, 1000 pmol/mouse
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Administration:ICV; 20 min before the test
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Result:Exerted an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse.
Chemical Information
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Molecular Weight 1610.96 (free acid)
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Formula C75H123N19O18S.xC2HF3O2
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Sequence
Leu-Glu-Ser-Ile-Phe-Arg-Ser-Leu-Leu-Phe-Arg-Val-Met
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Sequence Shortening
LESIFRSLLFRVM
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
[1]. C Klein, et al. Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Nat Biotechnol. 1998 Dec;16(13):1334-7. [Content Brief]
[2]. Phuong Doan, et al. Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity. Cells. 2021 Aug 3;10(8):1975. [Content Brief]
[3]. Yoo Jung Park, et al. A novel antimicrobial peptide acting via formyl peptide receptor 2 shows therapeutic effects against rheumatoid arthritis. Sci Rep. 2018 Oct 2;8(1):14664. [Content Brief]
[4]. Hui Zhao, et al. Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors. Peptides. 2016 Sep;83:16-20. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MMK1 TFA Related Classifications
HY-P1117A Related Classifications
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