Δ4-Dafachronic acid
Based on 1 Customer Validation
Δ4‑Dafachronic acid is an endogenous steroid hormone, an agonist of the DAF‑12 nuclear receptor, and a key ligand for the vitamin D receptor (VDR). Δ4‑Dafachronic acid promotes the active escape developmental trajectory in Austrofundulus limnaeus embryos even under diapause‑inducing conditions. Δ4‑Dafachronic acid is suitable for research on the developmental biology.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.93%
- CAS 番号: 23017-97-2
- 分子式: C27H42O3
- 分子量:414.62
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
Δ4-Dafachronic acid (0.3 mM) is the preferred substrate for the SDENChol_v1_11189 ACS enzyme[2].
Δ4-dafachronic acid (2.3 μM; 3-6 days) promotes molting of Haemonchus contortus L3 to L4 in cell-free in vitro culture[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Austrofundulus limnaeus embryos[1]
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Dosage:25 μM; 50 μM; 75 μM
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Administration:immersion in embryo media; daily media change
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Result:Induced ~15% of embryos to follow escape trajectory and ~85% to enter diapause at 25 μM.
Induced ~40% of embryos to follow escape trajectory and ~60% to enter diapause at 50 μM.
Induced ~90% of embryos to follow escape trajectory and ~10% to enter diapause at 75 μM.
Produced escape embryos with developmental rate and pattern indistinguishable from normal escape embryos.
Resulted in delayed development for embryos that entered diapause despite treatment.
化学情報
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CAS 番号 23017-97-2
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性状 Solid
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分子量 414.62
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分子式 C27H42O3
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Color White to off-white
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SMILES
CC(C(O)=O)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : ≥ 2.5 mg/mL (6.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
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- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Romney ALT, et al. Temperature-dependent vitamin D signaling regulates developmental trajectory associated with diapause in an annual killifish. Proc Natl Acad Sci U S A. 2018;115(50):12763-12768. [Content Brief]
[2]. Warnke M, et al. Functional Characterization of Three Specific Acyl-Coenzyme A Synthetases Involved in Anaerobic Cholesterol Degradation in Sterolibacterium denitrificans Chol1S. Appl Environ Microbiol. 2018;84(7):e02721-17. Published 2018 Mar 19. [Content Brief]
[3]. Niciura SCM, et al. In vitro culture of parasitic stages of Haemonchus contortus. Rev Bras Parasitol Vet. 2023;32(1):e010122. Published 2023 Jan 13. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4118 mL | 12.0592 mL | 24.1185 mL | 60.2962 mL |
| 5 mM | 0.4824 mL | 2.4118 mL | 4.8237 mL | 12.0592 mL |
Δ4-Dafachronic acid 関連分類
HY-131492 関連分類
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- Δ4-Dafachronic acid
- 23017-97-2
- Endogenous Metabolite
- VD/VDR
- Sterolibacterium denitrificans Chol1S
- Haemonchus contortus L4
- acyl-coenzyme A synthetase
- Haemonchus contortus L3
- Austrofundulus limnaeus embryos
- vitamin D receptor
- Haemonchus contortus
- anaerobic cholesterol degradation pathway
- Inhibitor
- inhibitor
- inhibit