AKP-001
AKP-001 is an inhibitor of p38 mitogen-activated protein kinase (p38 MAPK). AKP-001 can inhibit the production of inflammatory cytokines and can be used for research in rheumatoid arthritis and inflammatory bowel disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 897644-83-6
- 分子式: C21H13ClF2N4O2
- 分子量:426.80
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| THP-1 | IC50 |
49.1 nM
Compound: 26d
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Antiinflammatory activity in human THP1 cells assessed as LPS-induced TNFalpha secretion at 15 uM after 2 hrs by ELISA in presence of 10% fetal calf serum
Antiinflammatory activity in human THP1 cells assessed as LPS-induced TNFalpha secretion at 15 uM after 2 hrs by ELISA in presence of 10% fetal calf serum
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[PMID: 24938496] |
化学情報
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CAS 番号 897644-83-6
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分子量 426.80
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分子式 C21H13ClF2N4O2
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SMILES
O=C(NC1=C(C2=NC=NC=C2)C(C3=CC=C(F)C=C3)=NO1)CC4=C(F)C=CC=C4Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AKP-001 関連分類
HY-100278 関連分類
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