AST5902
AST5902 is the active metabolite of Furmonertinib (HY-112870) with antitumor activity, and acts as a EGFR inhibitor. AST5902 inhibits CYP3A4 mRNA transcription at low concentrations and induces CYP3A4 mRNA expression at high concentrations. AST5902 can be used in research related to non-small cell lung cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2412155-74-7
- 分子式: C27H29F3N8O2
- 分子量:554.57
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
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CYP3A4 |
EGFR |
体外実験
AST5902 exhibits anti-tumor activity comparable to that of its parent compound Furmonertinib (HY-112870), a potent EGFR inhibitor.[1]
AST5902 is generated via CYP3A4-mediated N-demethylation of Furmonertinib in human liver microsomes[2].
AST5902 (0.003‑5 μM) modulates CYP3A4 mRNA expression in primary human hepatocytes, exhibiting weak to moderate CYP3A4 induction activity with an EC50 ranging from 0.13‑0.68 μM, and inhibits CYP3A4 mRNA transcription at low concentrations[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2412155-74-7
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分子量 554.57
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分子式 C27H29F3N8O2
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SMILES
C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(C)CCNC)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AST5902 関連分類
HY-138627 関連分類
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