Axl-IN-18
Axl-IN-18 (compound 25c) is a potent and selective type II AXL inhibitor. Axl-IN-18 shows excellent AXL inhibitory activity (IC50=1.1 nM) and 343-fold selectivity over the highly homologous kinase MET in biochemical assays (IC50=377 nM). Axl-IN-18 significantly inhibits AXL-driven cell proliferation, dose-dependently suppresses 4T1 cell migration and invasion, and induces apoptosis. Axl-IN-18 shows noticeable antitumor efficacy in a BaF3/TEL-AXL xenograft model.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3040329-68-5
- 分子式: C32H26FN5O4
- 分子量:563.58
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| EBC-1 | IC50 |
1805.7 nM
Compound: 25c
|
Antiproliferative activity against human EBC-1 cells
Antiproliferative activity against human EBC-1 cells
|
[PMID: 38169272] |
化学情報
-
CAS 番号 3040329-68-5
-
分子量 563.58
-
分子式 C32H26FN5O4
-
SMILES
O=C1C2=C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OC)=C5)C5=NC=N4)C=C3)N=CC=C2N(C)C=C1C6=CC=CC(C)=C6
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Axl-IN-18 関連分類
HY-162103 関連分類
Powered by Bioz