Complement factor I
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.21 Serine endopeptidases > 3.4.21.45 complement factor I
Complement factor I is a regulatory serine protease in family S1 that inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage; cleavage of C3b requires binding to cofactor factor H or complement receptor CR1, cleavage of iC3b requires CR1, and cleavage of C4b requires C4b-binding protein. By damping complement activation it prevents host-tissue injury. It appears in viruses and cellular organisms.
Complement factor I is a regulatory serine protease in family S1 that inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage; cleavage of C3b requires binding to cofactor factor H or complement receptor CR1, cleavage of iC3b requires CR1, and cleavage of C4b requires C4b-binding protein. By damping complement activation it prevents host-tissue injury. It appears in viruses and cellular organisms.
生物医学辞典
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