158181-47-6
Chemical Structure
Disorazol A
- CAS 番号: 158181-47-6
- Formula:C43H54N2O10
- Molecular Weight:758.90
InChIKey: FRFRWOXVYJSPCG-ZRTDKHHTSA-N
SMILES: O=C(C1=COC(C[C@@H](OC)C=CC=CC=CC[C@@H](C(C)(C)[C@@H](O)/C=C/C)OC2=O)=N1)O[C@H](C(C)(C)[C@@H](O)/C=C/C)CC=C[C@@]3([H])O[C@@]3([H])C=CC=CC4=NC2=CO4
Biological Activity: Disorazol A1 is an tubulin inhibitor with antifungal activity. Disorazol A1 functions by inhibiting tubulin polymerization, interfering with microtubule formation, blocking mitosis, thus arresting the cell cycle at the G2/M phase and inducing apoptosis. Disorazol A1 also exhibits an inhibitory effect against L929 mouse fibroblasts with an IC50 value of 3 pM. Disorazol A1 causes the accumulation of p53 protein in the cell nucleus. Disorazol A1 is promising for research of cancers[1].
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Disorazol A | Disorazol A1 is an tubulin inhibitor with antifungal activity. Disorazol A1 functions by inhibiting tubulin polymerization, interfering with microtubule formation, blocking mitosis, thus arresting the cell cycle at the G2/M phase and inducing apoptosis. Disorazol A1 also exhibits an inhibitory effect against L929 mouse fibroblasts with an IC50 value of 3 pM. Disorazol A1 causes the accumulation of p53 protein in the cell nucleus. Disorazol A1 is promising for research of cancers. | |||||||||||||||||||||
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Keywords
