CDK2 degrader 2
Based on 1 Customer Validation
CDK2 degrader 2 (Compound I-10) is a PROTAC degrader for CDK2 that degrades CDK2 in MKN1 cell with a DC50 <100 nM.
(Pink: CDK2 ligand (HY-176124); Blue: Cereblon ligand (HY-45512); Black: linker (HY-W687952)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.51%
- CAS 番号: 3030271-16-7
- 分子式: C46H57ClN10O6S
- 分子量:913.53
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
More
生物活性
CDK2 degrader 2 selectively degrades CDK2 through the ubiquitin-proteasome pathway (UPP)[1].
Cyclin-dependent kinase (CDK) is a serine/threonine kinase that regulates cell cycle progression and cell division, followed by the heterodimerized with regulatory subunits known as cyclins, such as cyclin E1. Dysfunction of CDK2 leads to the proliferation inhibition of cancer cells, which can be used in anticancer researchs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 3030271-16-7
-
性状 Solid
-
分子量 913.53
-
分子式 C46H57ClN10O6S
-
Color White to off-white
-
SMILES
O=C1C(Cl)=CC2=C(N1C(C)C)N=C(NC3=CC=C(S(=O)(C4CCN(C5CCN(CC6CCN(CC6)C7=C(N(C)C(N8C9C(NC(CC9)=O)=O)=O)C8=CC=C7)CC5)CC4)=O)C=C3C)N=C2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (109.47 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (267 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0947 mL | 5.4733 mL | 10.9465 mL | 27.3664 mL |
| 5 mM | 0.2189 mL | 1.0947 mL | 2.1893 mL | 5.4733 mL | |
| 10 mM | 0.1095 mL | 0.5473 mL | 1.0947 mL | 2.7366 mL | |
| 15 mM | 0.0730 mL | 0.3649 mL | 0.7298 mL | 1.8244 mL | |
| 20 mM | 0.0547 mL | 0.2737 mL | 0.5473 mL | 1.3683 mL | |
| 25 mM | 0.0438 mL | 0.2189 mL | 0.4379 mL | 1.0947 mL | |
| 30 mM | 0.0365 mL | 0.1824 mL | 0.3649 mL | 0.9122 mL | |
| 40 mM | 0.0274 mL | 0.1368 mL | 0.2737 mL | 0.6842 mL | |
| 50 mM | 0.0219 mL | 0.1095 mL | 0.2189 mL | 0.5473 mL | |
| 60 mM | 0.0182 mL | 0.0912 mL | 0.1824 mL | 0.4561 mL | |
| 80 mM | 0.0137 mL | 0.0684 mL | 0.1368 mL | 0.3421 mL | |
| 100 mM | 0.0109 mL | 0.0547 mL | 0.1095 mL | 0.2737 mL |
CDK2 degrader 2 関連分類
HY-163815 関連分類
Powered by Bioz