Clesitamig
Based on 1 Customer Validation
Clesitamig (ALPS-12) is a trispecific T cell engager with two CD3/CD137 dual-specific Fabs and one DLL3 Fab. Clesitamig engages CD3 and CD137 on T cells to activate and co-stimulate T cells, promoting their proliferation, survival, and antitumor activity. Clesitamig binds to DLL3 on tumor cells for tumor-specific recognition. Clesitamig can be used for the research of small cell lung cancer (SCLC).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.78%
- CAS 番号: 2930861-48-4
- 分子量:195.836 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Fab-kappa_crossover-IgG1-kappa_tetrekisdisulfide
Human
CD3E & TNFRSF9 & DLL3
Clesitamig successfully engages its targets to activate CD3 and CD137 signaling, as demonstrated by a dose-dependent increase in NFAT and NF-κB activity in Jurkat reporter cells cocultured with DLL3-positive cells[2].
Clesitamig induces cytotoxicity against SCLC cell lines co-cultured with human PBMCs, with EC50 values in the two-digit picomolar range[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Fab-kappa_crossover-IgG1-kappa_tetrekisdisulfide
ELISA, FACS, Functional assay
化学情報
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CAS 番号 2930861-48-4
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性状 Liquid
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分子量 195.836 kDa
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Color Colorless to light yellow
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SMILES
[Clesitamig]
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別名
ALPS-12; RG-6524; RO 7616789
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (257 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Clesitamig 関連分類
HY-P990981 関連分類
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