COX-2-IN-59
COX-2-IN-59 is a potent and selective COX-2 inhibitor with an IC50 of 0.052 μM. COX-2-IN-59 exhibits 200-fold selectivity over COX-1 (IC50 = 11.16 μM). COX-2-IN-59 reduces COX-2 levels, induces cell cycle arrest, and triggers apoptosis by increasing Bax expression, decreasing Bcl-2 levels, and activating caspase-3. COX-2-IN-59 can be used for the research of colon cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C18H19N3O6S
- 分子量:405.42
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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生物活性
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COX-2 0.052 μM (IC50) |
COX-1 11.16 μM (IC50) |
COX-2-IN-59 (compound 5d) (12.5-100 μM; 24 h) inhibits A-549, HOS, MCF‐7, HT‐29, PC3, and Caco‐2 cell growth with IC50s of 4, 67.3, 30.5, 8.5, 29.1, and 2.6 μM, respectively[1].
COX-2-IN-59 (2.6 μM; 24 h) induces G1/S cell cycle arrest, and triggers apoptosis in Caco-2 cells by increasing Bax expression, decreasing Bcl-2 levels, and activating caspase-3[1].
COX-2-IN-59 (2.6 μM; 24 h) significantly reduces COX-2 levels to 3.858 ng/mL (0.494‐fold relative to control) in Caco-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A-549, HOS, MCF-7, HT-29, PC3, and Caco-2 cells
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Concentration:12.5-100 μM
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Incubation Time:24 h
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Result:Inhibited A-549, HOS, MCF-7, HT-29, PC3, and Caco-2 cell growth with IC50s of 4, 67.3, 30.5, 8.5, 29.1, and 2.6 μM, respectively.
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Cell Line:Caco-2
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Concentration:2.6 μM
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Incubation Time:24 h
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Result:Demonstrated potent proapoptotic activity in Caco-2 cells, inducing a nearly eightfold increase in total apoptosis (24.38% vs. 3.16% in controls). Induced a dramatic 63-fold increase (15.86% vs. 0.25%) in late apoptosis, and an 11-fold increase (4.85% vs. 0.42%) in early apoptosis.
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Cell Line:Caco-2
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Concentration:2.6 μM
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Incubation Time:24 h
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Result:Showed a dramatic decrease in G2/M phase cells in the treated group (3.82%) compared to the control group (22.05%). Significantly increased cells in the G0/G1 phase (64.06% vs. 48.29% in control). Induced G1/S phase cell cycle arrest.
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Cell Line:Caco-2
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Concentration:2.6 μM
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Incubation Time:24 h
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Result:Induced the expression of Bax while suppressing the expression of Bcl‐2, ultimately leading to an increased expression of caspase‐3.
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Cell Line:Caco-2
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Concentration:2.6 μM
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Incubation Time:24 h
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Result:Significantly reduced COX-2 levels to 3.858 ng/mL (0.494‐fold relative to control).
化学情報
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分子量 405.42
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分子式 C18H19N3O6S
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SMILES
CC(NC1=CC=C(OCC(N/N=C/C2=CC=C(OS(=O)(C)=O)C=C2)=O)C=C1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
COX-2-IN-59 関連分類
HY-179125 関連分類
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