EGIS-7625
EGIS-7625 is an orally active and selective competitive antagonist of 5-HT2B receptor, with a human Ki value of 1 nM. EGIS-7625 shows low affinity for 5-HT2A and 5-HT2C receptors. The pKi values of EGIS-7625 for human 5-HT2B, 5-HT2A and 5-HT2C are 9.0, 6.2 and 7.7, respectively. EGIS-7625 alleviates mCPP-induced hypoactivity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 755040-97-2
- 分子式: C18H24Cl2N4O2
- 分子量:399.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
5-HT Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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5-HT2A Receptor |
5-HT2B Receptor |
5-HT2C Receptor |
5-HT2B Receptor 9.0 (pKi) |
5-HT2A Receptor 6.2 (pKi) |
5-HT2C Receptor 7.7 (pKi) |
EGIS-7625 (1-10 nM) acts as a potent competitive antagonist of 5-HT2B receptor-mediated contraction in rat fundus strips, with a pA2 value of 9.4[1].
EGIS-7625 (1-30 μM; 30 minutes) acts as a weak competitive antagonist of 5-HT2A receptor-mediated contraction in rabbit pulmonary artery strips, with a pA2 value of 6.7[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
EGIS-7625 (3-30 mg/kg; p.o.; single administration) antagonizes mCPP-induced 5-HT2C receptor-mediated hypoactivity in rats at the highest dose of 30.0 mg/kg, while no significant effects are observed at lower doses[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar (male, 180-240 g) rats[1]
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Dosage:3, 10, 30 mg/kg
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Administration:p.o.; single dose
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Result:Significantly diminished mCPP-induced hypomotility at 30 mg/kg p.o.
Did not produce a significant effect at 3.0 mg/kg and 10.0 mg/kg p.o.
化学情報
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CAS 番号 755040-97-2
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分子量 399.31
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分子式 C18H24Cl2N4O2
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SMILES
NC1=CC(N2CCN(CC3=CC=CC=C3)CC2)=C([N+]([O-])=O)C=C1C.Cl.Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
EGIS-7625 関連分類
HY-123480 関連分類
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