755040-97-2
Chemical Structure
EGIS-7625
- CAS No.: 755040-97-2
- Formula:C18H24Cl2N4O2
- Molecular Weight:399.31
IUPAC Name: 5-(4-benzylpiperazin-1-yl)-2-methyl-4-nitroaniline dihydrochloride
InChIKey: AYRFPZMTRYDWGP-UHFFFAOYSA-N
SMILES: NC1=CC(N2CCN(CC3=CC=CC=C3)CC2)=C([N+]([O-])=O)C=C1C.Cl.Cl
Biological Activity: EGIS-7625 is an orally active and selective competitive antagonist of 5-HT2B receptor, with a human Ki value of 1 nM. EGIS-7625 shows low affinity for 5-HT2A and 5-HT2C receptors. The pKi values of EGIS-7625 for human 5-HT2B, 5-HT2A and 5-HT2C are 9.0, 6.2 and 7.7, respectively. EGIS-7625 alleviates mCPP-induced hypoactivity[1].
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EGIS-7625 | EGIS-7625 is an orally active and selective competitive antagonist of 5-HT2B receptor, with a human Ki value of 1 nM. EGIS-7625 shows low affinity for 5-HT2A and 5-HT2C receptors. The pKi values of EGIS-7625 for human 5-HT2B, 5-HT2A and 5-HT2C are 9.0, 6.2 and 7.7, respectively. EGIS-7625 alleviates mCPP-induced hypoactivity. | |||||||||||||||||||||
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Keywords
