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DIP2A - disco interacting protein 2 homolog A Gene

Also Known as DIP2; C21orf106

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 23181

About DIP2A

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:46,458,891-46,583,871 (from NCBI)

This gene has 13 transcripts (splice variants), 189 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 7.3), prostate (RPKM 6.1) and 25 other tissues.

Summary

The protein encoded by this gene may be involved in axon patterning in the central nervous system. This gene is not highly expressed. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

DIP2A Products (10)

mRNA	Protein	Name
NM_001146115.2	NP_001139587.1	disco-interacting protein 2 homolog A isoform f
NM_001146116.2	NP_001139588.1	disco-interacting protein 2 homolog A isoform g
NM_001353942.2	NP_001340871.1	disco-interacting protein 2 homolog A isoform h
NM_001353943.2	NP_001340872.1	disco-interacting protein 2 homolog A isoform a
NM_001353944.2	NP_001340873.1	disco-interacting protein 2 homolog A isoform i
NM_001410751.1	NP_001397680.1	disco-interacting protein 2 homolog A isoform j
NM_015151.4	NP_055966.2	disco-interacting protein 2 homolog A isoform a
NM_206889.3	NP_996772.1	disco-interacting protein 2 homolog A isoform b
NM_206890.3	NP_996773.1	disco-interacting protein 2 homolog A isoform c
NM_206891.3	NP_996774.1	disco-interacting protein 2 homolog A isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	20054002	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	20860622	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cell surface	IDA IDA: Inferred from direct assay	20054002	GOA
located in membrane	IDA IDA: Inferred from direct assay	20054002	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DIP2A Protein Structure

DMAP_binding

AMP-binding

0
300
600
900
1200
1571 a.a.

Protein Preferred Names	Protein Names
disco-interacting protein 2 homolog A	DIP2 disco-interacting protein 2 homolog A

DIP2A Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	DIP2A	Q14689	FST	Homo sapiens	P19883	Competition Binding	20860622
Intra	DIP2A	Q14689	FSTL1	Homo sapiens	Q12841	Y2H	20860622
Cross	DIP2A	Q14689	Fstl1	Mus musculus	Q62356	Anti Tag CoIP	20054002
Intra	DIP2A	Q14689	TRIP13	Homo sapiens	Q15645	Validated Y2H	25416956
Intra	DIP2A	Q14689	TRIP13	Homo sapiens	Q15645	Y2H Array	25416956
Intra	DIP2A	Q14689	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	25416956
Intra	DIP2A	Q14689	GPATCH2L	Homo sapiens	Q9NWQ4	Y2H Prey Pooling	25416956
Intra	DIP2A	Q14689	GPATCH2L	Homo sapiens	Q9NWQ4	Y2H Array	25416956
Intra	DIP2A	Q14689	CEP44	Homo sapiens	Q9C0F1	Y2H Prey Pooling	25416956
Intra	DIP2A	Q14689	ATOSB	Homo sapiens	Q7L5A3	Y2H Prey Pooling	25416956
Intra	DIP2A	Q14689	ATOSB	Homo sapiens	Q7L5A3	Validated Y2H	25416956
Intra	DIP2A	Q14689	ATOSB	Homo sapiens	Q7L5A3	Y2H Array	25416956
Intra	DIP2A	Q14689	TGFB1	Homo sapiens	P01137	SPR	20860622

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Malignant Histiocytic Disease	Histiocytic Disorders, Malignant
Dyslexia
Hermansky-Pudlak Syndrome 5	HPS5 Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Delta Storage Pool Disease Hermansky-Pudlak Syndrome, Type 5 Platelet Storage Pool Deficiency Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Reading Disorder	Specific Reading Disorder Reading Dyslexia Developmental Reading Disorder
Middle Cerebral Artery Infarction	Infarction, Middle Cerebral Artery Infarction Middle Cerebral Artery
Learning Disability	Learning Disabilities Learning Disorders Academic Skill Disorder Learning Disorder
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Chromosome 22q11.2 Deletion Syndrome, Distal	22q11.2 Deletion Syndrome Autosomal Dominant Opitz G/Bbb Syndrome Catch22 Cayler Cardiofacial Syndrome Conotruncal Anomaly Face Syndrome Digeorge Syndrome Sedlackova Syndrome Shprintzen Syndrome Velocardiofacial Syndrome 22q11.2 Distal Deletion Syndrome Distal 22q11.2 Microdeletion Syndrome 22q11.2ds Vcfs Velo-Cardio-Facial Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Deletion 22q11.2 Syndrome 22q11ds Catch 22 Digeorge Sequence Microdeletion 22q11.2 Monosomy 22q11 Takao Syndrome Distal Del(22)(Q11.2) Distal Monosomy 22q11.2 Catch 22 Syndrome Chromosome Deletion Syndrome 22q11.2, Distal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS03772	DIP2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	DIP2A	VGNC	VGNC:28066
Macaca mulatta	DIP2A	VGNC	VGNC:71641
Felis catus	DIP2A	VGNC	VGNC:61492
Rattus norvegicus	DIP2A	RGD	RGD:1582897
Mus musculus	DIP2A	MGD	MGI:2385920
Others	DIP2A	NCBI