HPSE2 - heparanase 2 (inactive) Gene
Also Known as UFS; HPA2; HPR2; UFS1
生物種: Homo sapiens
About HPSE2
This gene has 6 transcripts (splice variants), 93 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in esophagus (RPKM 5.3), prostate (RPKM 4.1) and 13 other tissues.
Summary
This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
HPSE2 Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001166244.1 | NP_001159716.1 | inactive heparanase-2 isoform 2 |
| NM_001166245.1 | NP_001159717.1 | inactive heparanase-2 isoform 3 |
| NM_001166246.1 | NP_001159718.1 | inactive heparanase-2 isoform 4 |
| NM_021828.5 | NP_068600.4 | inactive heparanase-2 isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables heparan sulfate proteoglycan binding |
IDA
IDA: Inferred from direct assay
|
20576607 | GOA |
| NOT enables heparanase activity |
IDA
IDA: Inferred from direct assay
|
20576607 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| located in extracellular matrix |
IDA
IDA: Inferred from direct assay
|
20576607 | GOA |
HPSE2 Protein Structure
Glyco_hydro_79n: Glycosyl hydrolase family 79, N-terminal domain (196 - 408)
- 0
- 100
- 200
- 300
- 400
- 500
- 592 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
inactive heparanase-2 |
|
関連疾患
| Diseases | Alias | |
|---|---|---|
| Urofacial Syndrome 1 |
|
|
| Cakut |
|
|
| Lagophthalmos |
|
|
| Prune Belly Syndrome |
|
|
| Li-Fraumeni Syndrome 1 |
|
|
| Neurogenic Bladder |
|
|
| Corpus Callosum, Agenesis Of, With Abnormal Genitalia |
|
|
| Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1 |
|
|
| Vesicoureteral Reflux |
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Rattus norvegicus | HPSE2 | RGD | RGD:1307959 |
| Macaca mulatta | HPSE2 | VGNC | VGNC:106058 |
| Mus musculus | HPSE2 | MGD | MGI:2685814 |
| Others | HPSE2 | NCBI |