CARD6 - caspase recruitment domain family member 6 Gene

Also Known as CINCIN1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 84674

About CARD6

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:40,841,367-40,855,354 (from NCBI)

This gene has 2 transcripts (splice variants), 84 orthologues and 1 paralogue. Ubiquitous expression in gall bladder (RPKM 6.9), spleen (RPKM 6.3) and 24 other tissues.

Summary

This gene encodes a protein that contains a Caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008]

CARD6 Products (1)

mRNA Protein Name
NM_032587.4 NP_115976.2 caspase recruitment domain-containing protein 6

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
16418290 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CARD6 Protein Structure

CARD

CARD: Caspase recruitment domain (9 - 89)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1037 a.a.
Protein Preferred Names Protein Names

caspase recruitment domain-containing protein 6

  • CARD-containing inhibitor of Nod1 and Cardiak-induced NF-kB activation

CARD6 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CARD6 Q9BX69 RIPK2 Homo sapiens O43353
Anti Tag CoIP
16418290
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Glioblastoma Mesenchymal Subtype
Inflammatory Bowel Disease 3

  • IBD3
Inflammatory Bowel Disease 6

  • IBD6
Inflammatory Bowel Disease 1

  • Inflammatory Bowel Disease 1

  • IBD1

  • Crohn Disease-Associated Growth Failure

  • Crohn Disease

  • Regional Enteritis

  • Ulcerative Colitis

  • Crohn Disease-Associated Growth Failure, Susceptibility To

  • Inflammatory Bowel Disease 1, Crohn Disease

  • Bowel Disease, Inflammatory, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS01921 CARD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris CARD6 VGNC VGNC:38717
Mus musculus CARD6 MGD MGI:3032959
Macaca mulatta CARD6 VGNC VGNC:70569
Rattus norvegicus CARD6 RGD RGD:1305805
Bos taurus CARD6 VGNC VGNC:26763
Felis catus CARD6 VGNC VGNC:60367
Others CARD6 NCBI