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製品番号: HY-181604

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MDH2-IN-2

MDH2-IN-2 is an orally active MDH2 inhibitor with an IC₅₀ of 5.9 μM. MDH2-IN-2 reduces the levels of senescence markers and senescence-associated secretory phenotype (SASP) factors in mammalian cell models. MDH2-IN-2 extends the lifespan and improves the healthspan of Caenorhabditis elegans. MDH2-IN-2 alleviates tissue senescence in aged mice, inhibits SASP factors, and restores liver and kidney functions. MDH2-IN-2 is applicable for senescence-related research.

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CAS 番号: 3047410-41-0
分子式: C₃₁H₄₀N₂O₄S
分子量:536.73

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

MDH2-IN-2 構造式

CAS 番号: 3047410-41-0

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生物活性
- 製品説明
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

体外実験

MDH2-IN-2 (Compound 28i) inhibits the activity of recombinant human MDH1 enzyme, with an IC₅₀ value of 25.3 μM^[1].
MDH2-IN-2 (1 μM; 3 days) significantly downregulates the mRNA levels of various SASP factors in MRC-5 cells, and reduces the expression level of p53 protein and the proportion of SA-β-gal-positive cells in replicatively senescent MRC-5 cells^[1].
MDH2-IN-2 (1 μM) significantly reduces the proportion of SA-β-gal-positive NRK-52E cells that undergo senescence induced by Mitomycin C (HY-13316)^[1].
MDH2-IN-2 (1 μM; 5 days) significantly reduces the expression level of p16 protein and the proportion of SA-β-gal positive cells in replicative senescent MEFs^[1].
MDH2-IN-2 (1 μM; 5-60 minutes) undergoes rapid metabolic turnover in both human and mouse liver microsomes, with corresponding T_1/2 values of 1.15 min and 1.10 min, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

MRC-5 cells
Concentration:

1 μM
Incubation Time:

3 days
Result:

Significantly downregulated mRNA expression of senescence-associated secretory phenotype (SASP) factors IL-1α, IL-1β, IL-8, CXCL-1, MMP-1, and MMP-3.

Western Blot Analysis^[1]

Cell Line:

Replicatively senescent human embryonic lung fibroblasts (MRC-5, passage 32)
Concentration:

1 μM
Incubation Time:

3 days
Result:

Significantly reduced the protein expression level of p53, a key senescence-associated cell cycle regulator.

Western Blot Analysis^[1]

Cell Line:

Replicatively senescent mouse embryonic fibroblasts (MEFs, passage 7)
Concentration:

1 μM
Incubation Time:

5 days
Result:

Significantly reduced the protein expression level of p16, a key senescence-associated cyclin-dependent kinase inhibitor.

Parmacokinetics

Species	Dose	Route	T_max	AUC_0-last	T_1/2
Mice^[1]	10 mg/kg	p.o.	0.25 h	6.38	0.79 h
Mice^[1]	5 mg/kg	i.v.	/	12.5	0.62 h

体内実験

MDH2-IN-2 (100 μM; incorporated into NGM plates; continuous exposure) extends the mean lifespan of wild-type Caenorhabditis elegans by 15.49% and improves multiple healthspan-related indicators^[1].
MDH2-IN-2 (0-50 mg/kg; i.g.; once daily; 3 weeks) significantly inhibits multiple SASP factors in premature senescent male C57BL/6J mice induced by Doxorubicin (HY-15142A)^[1].
MDH2-IN-2 (5-10 mg/kg; i.g.; once daily; 3 months) reverses age-related serum biochemical abnormalities, inhibits the production of SASP factors, reduces the expression of renal senescence markers, and improves renal histological morphology in naturally aged male C57BL/6J mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

wild-type N2^[1]
Dosage:

100 μM
Administration:

incorporation into NGM plates; continuous exposure
Result:

Extended mean lifespan by 15.49% compared to controls.
Significantly improved egg-laying capacity compared to controls.
Increased pharyngeal pumping rate compared to controls.
Maintained body bend frequency relative to controls.

Animal Model:

C57BL/6J (male, 8 weeks old, doxorubicin-induced premature aging)^[1]
Dosage:

10 mg/kg; 20 mg/kg; 50 mg/kg
Administration:

i.g.; once daily; 3 weeks
Result:

Significantly reduced serum levels of SASP factors including IL-1β, IL-6, CXCL-1, TNF-α, MMP-1, and MMP-2 compared to Dox-only treated male mice.

Animal Model:

C57BL/6J (male, 21 months old, naturally aged)^[1]
Dosage:

5 mg/kg; 10 mg/kg
Administration:

i.g.; once daily; 3 months
Result:

Significantly reduced age-related increases in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and uric acid (UA) to levels comparable to young control mice.
Markedly reduced serum levels of SASP factors including IL-6, IL-1β, MMP-1, MMP-2, CXCL-1, GDF-15, and TNF-α.
Downregulated renal tissue expression of senescence markers p53, p21, and p16.
Significantly ameliorated age-related glomerular atrophy, inflammatory infiltration, and collagen fiber accumulation in the kidney.

化学情報

CAS 番号 3047410-41-0
分子量 536.73
分子式 C₃₁H₄₀N₂O₄S
SMILES

O=S(C1=CC=C(C=C1)CCNC(C2=CC=CC(OCC3CCCC3)=C2)=O)(NC45C[C@@H]6C[C@H](C5)C[C@@H](C6)C4)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (277 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wu L, et al. Discovery of Novel MDH2 Inhibitor 28i by Secondary Development of Glibenclamide with Potent Antiaging Activities. J Med Chem. 2026;69(3):2400-2423. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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