Nicoxamat
Based on 1 Customer Validation
Nicoxamat (N-Hydroxynicotinamide) is a HCV inhibitor as well as a selective HDAC6 inhibitor. Nicoxamat is applicable to research related to hepatitis C virus (HCV) infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.05%
- CAS 番号: 5657-61-4
- 分子式: C6H6N2O2
- 分子量:138.13
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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HDAC6 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
450 μM
Compound: II
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Cytotoxicity against human HuH7 cells transfected with luc/neo plasmid assessed as cell viability after 72 hrs by MTT method
Cytotoxicity against human HuH7 cells transfected with luc/neo plasmid assessed as cell viability after 72 hrs by MTT method
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[PMID: 25937017] |
Nicoxamat (compound IIa) inhibits the proliferation of HCV full-length genomic replicons in Huh7 luc/neo cells, with an EC50 of 25 μM, a CC50 of 450 μM, and a selectivity index of 18[1].
Nicoxamat (20-100 μM) induces concentration-dependent hyperacetylation of α-tubulin in Huh7-luc/neo cells[1].
Nicoxamat (100 μM; 72 h) does not induce significant histone H3 acetylation in Huh7-luc/neo cells, indicating its selectivity for class I HDACs[1].
Nicoxamat (0-100 μM) exhibits concentration-dependent inhibition of HCV replicon and HDAC6 inhibitory activity in Huh7-luc/neo cells, with its HCV inhibitory activity being stronger than HDAC6 inhibitory activity at low concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh7-luc/neo cells
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Concentration:100 μM
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Incubation Time:72 h
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Result:Did not cause a significant increase in acetylated histone H3 levels at 100 μM after 72 hours of incubation.
化学情報
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CAS 番号 5657-61-4
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性状 Solid
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分子量 138.13
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分子式 C6H6N2O2
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Color White to off-white
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SMILES
O=C(NO)C=1C=NC=CC1
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別名
N-Hydroxynicotinamide
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (180.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.2396 mL | 36.1978 mL | 72.3956 mL | 180.9889 mL |
| 5 mM | 1.4479 mL | 7.2396 mL | 14.4791 mL | 36.1978 mL | |
| 10 mM | 0.7240 mL | 3.6198 mL | 7.2396 mL | 18.0989 mL | |
| 15 mM | 0.4826 mL | 2.4132 mL | 4.8264 mL | 12.0659 mL | |
| 20 mM | 0.3620 mL | 1.8099 mL | 3.6198 mL | 9.0494 mL | |
| 25 mM | 0.2896 mL | 1.4479 mL | 2.8958 mL | 7.2396 mL | |
| 30 mM | 0.2413 mL | 1.2066 mL | 2.4132 mL | 6.0330 mL | |
| 40 mM | 0.1810 mL | 0.9049 mL | 1.8099 mL | 4.5247 mL | |
| 50 mM | 0.1448 mL | 0.7240 mL | 1.4479 mL | 3.6198 mL | |
| 60 mM | 0.1207 mL | 0.6033 mL | 1.2066 mL | 3.0165 mL | |
| 80 mM | 0.0905 mL | 0.4525 mL | 0.9049 mL | 2.2624 mL | |
| 100 mM | 0.0724 mL | 0.3620 mL | 0.7240 mL | 1.8099 mL |
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