RX 801077
Based on 1 publication(s) in Google Scholar
RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 shows anti-inflammation and neuroprotection. RX 801077 has the potential for the research of traumatic brain injury (TBI).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 72583-92-7
- 分子式: C11H10N2O
- 分子量:186.21
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 RX 801077
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生物活性
製品説明
IC50 & Target
Ki: 70.1 nM (imidazoline I2 receptor)[2]
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:280-300 g, Male adult Sprague-Dawley rats (TBI model)[2]
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Dosage:5, 10, 20 mg/kg
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Administration:I.p.; twice daily for 3 days
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Result:Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex.
化学情報
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CAS 番号 72583-92-7
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分子量 186.21
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分子式 C11H10N2O
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SMILES
C1(C2=CC3=CC=CC=C3O2)=NCCN1
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別名
2 BFI free base
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Immunopathol Pharmacol
Agmatine suppresses the imidazoline I2 receptor/ribosomal S6 kinase 2/NF-κB signaling pathway regulating alveolar macrophage polarization and ameliorating sepsis-associated acute lung injury. [Abstract]2026 Jan-Dec:40:3946320261425360. PMID: 41728646
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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