RX 801077 hydrochloride
Based on 1 publication(s) in Google Scholar
RX 801077 hydrochloride (2 BFI) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 hydrochlorideshows anti-inflammation and neuroprotection. RX 801077 hydrochloride has the potential for the research of traumatic brain injury (TBI).
For research use only. We do not sell to patients.
- Purity: 99.20%
- CAS No.: 89196-95-2
- Formula: C11H11ClN2O
- Molecular Weight:222.67
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
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Publications Citing Use of MedChemExpress (MCE) RX 801077 hydrochloride
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Biological Activity
Ki: 70.1 nM (imidazoline I2 receptor)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:280-300 g, Male adult Sprague-Dawley rats (TBI model)[2]
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Dosage:5, 10, 20 mg/kg
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Administration:I.p.; twice daily for 3 days
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Result:Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex.
Chemical Information
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CAS No. 89196-95-2
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Appearance Solid
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Molecular Weight 222.67
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Formula C11H11ClN2O
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Color White to off-white
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SMILES
Cl[H].C1(C2=CC3=CC=CC=C3O2)=NCCN1
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Synonyms
2 BFI
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Immunopathol Pharmacol
Agmatine suppresses the imidazoline I2 receptor/ribosomal S6 kinase 2/NF-κB signaling pathway regulating alveolar macrophage polarization and ameliorating sepsis-associated acute lung injury. [Abstract]2026 Jan-Dec:40:3946320261425360. PMID: 41728646
Solvent & Solubility
DMSO : 20.83 mg/mL (93.55 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4910 mL | 22.4548 mL | 44.9095 mL | 112.2738 mL |
| 5 mM | 0.8982 mL | 4.4910 mL | 8.9819 mL | 22.4548 mL | |
| 10 mM | 0.4491 mL | 2.2455 mL | 4.4910 mL | 11.2274 mL | |
| 15 mM | 0.2994 mL | 1.4970 mL | 2.9940 mL | 7.4849 mL | |
| 20 mM | 0.2245 mL | 1.1227 mL | 2.2455 mL | 5.6137 mL | |
| 25 mM | 0.1796 mL | 0.8982 mL | 1.7964 mL | 4.4910 mL | |
| 30 mM | 0.1497 mL | 0.7485 mL | 1.4970 mL | 3.7425 mL | |
| 40 mM | 0.1123 mL | 0.5614 mL | 1.1227 mL | 2.8068 mL | |
| 50 mM | 0.0898 mL | 0.4491 mL | 0.8982 mL | 2.2455 mL | |
| 60 mM | 0.0748 mL | 0.3742 mL | 0.7485 mL | 1.8712 mL | |
| 80 mM | 0.0561 mL | 0.2807 mL | 0.5614 mL | 1.4034 mL |
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