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Cat. No.: HY-100904A

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RX 801077

(Synonyms: 2 BFI free base)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a K_i value of 70.1 nM. RX 801077 shows anti-inflammation and neuroprotection. RX 801077 has the potential for the research of traumatic brain injury (TBI).

For research use only. We do not sell to patients.

CAS No.: 72583-92-7
Formula: C₁₁H₁₀N₂O
Molecular Weight:186.21

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

RX 801077 Chemical Structure

CAS No.: 72583-92-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

K_i: 70.1 nM (imidazoline I2 receptor)^[2]

In Vivo

RX 801077 (5, 10, 20 mg/kg; i.p.; twice daily for 3 days) inhibits NLRP3 inflammasome-induced inflammation and necroptosis in a rat model of traumatic brain injury^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

280-300 g, Male adult Sprague-Dawley rats (TBI model)^[2]
Dosage:

5, 10, 20 mg/kg
Administration:

I.p.; twice daily for 3 days
Result:

Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex.

Chemical Information

CAS No. 72583-92-7
Molecular Weight 186.21
Formula C₁₁H₁₀N₂O
SMILES

C1(C2=CC3=CC=CC=C3O2)=NCCN1
Synonyms

2 BFI free base
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Int J Immunopathol Pharmacol

Agmatine suppresses the imidazoline I2 receptor/ribosomal S6 kinase 2/NF-κB signaling pathway regulating alveolar macrophage polarization and ameliorating sepsis-associated acute lung injury. [Abstract]

2026 Jan-Dec:40:3946320261425360. PMID: 41728646

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Carpéné C, et al. Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites. J Pharmacol Exp Ther. 1995 Feb;272(2):681-8. [Content Brief]

[2]. Ni H, et al. 2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury. Front Neurosci. 2019 Jun 26;13:674.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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