2. Neuronal Signaling
  3. Imidazoline Receptor
  4. RX 801077

RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 shows anti-inflammation and neuroprotection. RX 801077 has the potential for the research of traumatic brain injury (TBI).

For research use only. We do not sell to patients.

RX 801077 Chemical Structure

RX 801077 Chemical Structure

CAS No. : 72583-92-7

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Description

RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 shows anti-inflammation and neuroprotection. RX 801077 has the potential for the research of traumatic brain injury (TBI)[1][2].

IC50 & Target

Ki: 70.1 nM (imidazoline I2 receptor)[2]
In Vivo

RX 801077 (5, 10, 20 mg/kg; i.p.; twice daily for 3 days) inhibits NLRP3 inflammasome-induced inflammation and necroptosis in a rat model of traumatic brain injury[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 280-300 g, Male adult Sprague-Dawley rats (TBI model)[2]
Dosage: 5, 10, 20 mg/kg
Administration: I.p.; twice daily for 3 days
Result: Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex.
Molecular Weight

186.21

Formula

C11H10N2O
CAS No.
SMILES

C1(C2=CC3=CC=CC=C3O2)=NCCN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RX 801077 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RX 80107772583-92-72 BFIRX801077RX-801077Imidazoline Receptoranti-inflammationnecroptosisRIP1RIP3IL-1βtraumatic brain injuryInhibitorinhibitorinhibit

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