83 Results for "

MMP-3

" in MedChemExpress (MCE) Product Catalog:
Products (83)

83 Results for "MMP-3" in MCE Product Catalog:

  • Isoforms Recommended:
  • Targets Recommended:
  • Recombinant Proteins Recommended:
製品番号: HY-N1454R
CAS 番号: 29741-09-1
別名: Apigenin 7-O-glucuronide (Standard)
Apigenin-7-glucuronide (Standard) is the analytical standard of Apigenin-7-glucuronide. This product is intended for research and analytical applications. Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.
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製品番号: HY-P2185
CAS 番号: 158584-09-9
Target:  

MMP

研究分野:  

Others

NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .
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製品番号: HY-P3202
CAS 番号: 79955-99-0
別名: MMP-3; Stromelysin-1
Target:  

MMP

研究分野:  

Neurological Disease

Matrix metalloproteinase 3 (MMP-3) is a member of the class of zinc-dependent proteases that can degrade the extracellular matrix (ECM). Matrix metalloproteinase 3 palys an important role in the neuronal apoptotic process as well as in neuroinflammation. Matrix metalloproteinase 3 can be used in the study of neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD) .
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製品番号: HY-P2166A
Target:  

MMP

研究分野:  

Cancer

MMP3 inhibitor 3 (TFA) is an inhibitor of MMP3. MMP3 inhibitor 3 (TFA) can used to study breast cancer .
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製品番号: HY-N16408
CAS 番号: 1019854-22-8
Target:  

MMP Caspase

Berkeleyamide B is a dual matrix metalloproteinase-3 (MMP-3) and caspase-1 inhibitor. Berkeleyamide B is promising for research of cancers and inflammatory disease (e.g., rheumatoid arthritis) .
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製品番号: HY-RS08550
研究分野:  

Others

Mmp3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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製品番号: HY-152030
CAS 番号: 2734877-51-9
研究分野:  

Cancer

Tubulin/MMP-IN-2 is dual inhibitor of tubulin and matrix metalloproteinases. Tubulin/MMP-IN-2 can strongly inhibit tubulin polymerization and induces cell apoptosis. Tubulin/MMP-IN-2 has inhibitory activities against MMP-2, MMP-3 and MMP-9 with IC50 values of 24.95 μM, 31.60 μM and 22.37 μM, respectively. Tubulin/MMP-IN-2 can be used for the research of cancer .
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製品番号: HY-P3098
CAS 番号: 256394-94-2
Target:  

MMP

研究分野:  

Others

Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .
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製品番号: HY-167825
CAS 番号: 24506-68-1
Barakol is an anticancer and anxiolytic agent identified in Cassia siamea. Barakol inhibits MMP-3 activity and enhances the cytotoxicity and antimetastatic effects of Doxorubicin (HY-15142) against cancer cells. Barakol induces apoptosis via reactive oxygen species (ROS) production, upregulation of the Bax/Bcl-2 protein ratio, and activation of caspase-9. Barakol exerts anxiolytic activity with diazepam-like effects, increases spontaneous longitudinal smooth muscle contraction of rat ileum in a concentration-dependent manner (EC50 = 0.3 mM), and inhibits norepinephrine-induced contraction suppression. Barakol can be used in research related to anxiety, intestinal motility, and neuroblastoma [3] .
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製品番号: HY-18694
CAS 番号: 169799-04-6
Target:  

MMP

研究分野:  

Inflammation/Immunology

CGS 27023A is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A prevents cartilage degradation in stromelysin-induced rabbit cartilage degradation model. CGS 27023A can be used for study of arthritis .
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製品番号: HY-117464
CAS 番号: 1664361-37-8
Target:  

MMP

研究分野:  

Cardiovascular Disease

CM-352 (compound 5) is an inhibitor of matrix metalloproteinases (MMPs) (MMP-3: IC50=15 nM; MMP-10: IC50=12 nM). CM-352 has significant antifibrinolytic activity (EC50=0.7 nM) and can significantly prolong blood coagulation time. CM-352 can be used in anti-bleeding research .
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製品番号: HY-15768R
CAS 番号: 142880-36-2
別名: GM6001 (Standard); Galardin (Standard)
Target:  

MMP Reference Standards

研究分野:  

Cancer

Ilomastat (Standard) is the analytical standard of Ilomastat. This product is intended for research and analytical applications. Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1).
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製品番号: HY-137370
CAS 番号: 141018-30-6
別名: HENECA; 2-Hexynyl-NECA
研究分野:  

Neurological Disease

2-Hexynyl-5′-N-ethylcarboxamidoadenosine (HENECA) is a selective A2A adenosine receptor agonist. 2-Hexynyl-5′-N-ethylcarboxamidoadenosine increases intracellular cAMP level, and inhibits TNFα-evoked MMP-3 release. 2-Hexynyl-5′-N-ethylcarboxamidoadenosine induces Aβ42 production in SH-SY5Y cells [3].
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製品番号: HY-N1463R
CAS 番号: 29741-10-4
別名: Luteolin 7-glucuronide (Standard)
Luteolin 7-O-glucuronide (Standard) is the analytical standard of Luteolin 7-O-glucuronide. This product is intended for research and analytical applications. Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively .
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製品番号: HY-12270R
CAS 番号: 530141-72-1
Target:  

AP-1 MMP

研究分野:  

Others

T-5224 (Standard) is the analytical standard of T-5224. This product is intended for research and analytical applications. T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .
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製品番号: HY-110397G
CAS 番号: 1365803-52-6
KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .
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製品番号: HY-P3699A
Target:  

MMP Fluorescent Dye

研究分野:  

Others

TNO003 TFA is a selective fluorogenic substrate for stromelysin-1 (MMP-3). TNO003 TFA has higher selectivity for MMP-3 than MMP-1, MMP-2, MMP-7, MMP-8, MMP-9 and MMP-13. TNO003 TFA can be used for the determination of stromelysin activity (Ex/Em = 360/490 nm) .
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製品番号: HY-107617
CAS 番号: 1032822-42-6
Target:  

MMP

研究分野:  

Neurological Disease

PTIQ can suppress MMP-3 production, can enter the brain and provide neuroprotection. PTIQ has anti-inflammatory effects on microglial cells .
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製品番号: HY-N2259R
CAS 番号: 19431-84-6
別名: (+)-Curcumenol (Standard)
Curcumenol (Standard) ((+)-Curcumenol (Standard)) is the analytical standard of Curcumenol (HY-N2259). This product is intended for research and analytical applications. Curcumenol ((+)-Curcumenol) is a natural compound with oral efficacy, exhibiting an IC50 of 12.6 μM and a Ki of 10.8 μM against human CYP3A4. Curcumenol inhibits TNFα-induced phosphorylation/degradation of IκBα, phosphorylation/nuclear translocation of NF-κB p65, as well as the upregulation of MMP3, MMP9, MMP13, TRAF3, IL1RL1, TNFα and IL-1β. Curcumenol suppresses LPS-induced phosphorylation of Akt and p38 MAPK, as well as the production of pro-inflammatory mediators/proteins, and downregulates the SLC7A11/NF-κB/TGF-β pathway. Curcumenol binds to and inhibits the activation of Fyn and Lyn, blocks the function of downstream FcεRI signaling components, and reduces the release of allergic mediators/cytokines. Curcumenol upregulates the expression of KDM6B, and promotes chondrocyte proliferation and cartilage repair. Curcumenol induces ferroptosis and apoptosis, regulates the EMT process, and inhibits tumor growth and metastasis of triple-negative breast cancer. Curcumenol possesses anti-inflammatory, neuroprotective, antioxidant, antitumor, antiviral and hepatoprotective activities. Curcumenol can be used in research related to intervertebral disc degeneration, cancer, inflammation, central nervous system neurodegenerative diseases, allergic reactions and knee osteoarthritis [3] .
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製品番号: HY-14240
CAS 番号: 291533-11-4
純度:  99.81%
別名: PG 530742; PGE 530742; PGE 7113313
Target:  

MMP

研究分野:  

Cardiovascular Disease

PG 116800 (PGE 530742; PGE 7113313) is an orally active, selective and high-affinity inhibitor of MMP. PG 116800 acts as an inhibitor of ventricular remodeling, reduces left ventricular volumes and infarct zone collagen content, and improves ejection fraction. PG 116800 is generally well tolerated, but is associated with higher rates of arthralgia, joint stiffness, and dyspepsia. PG 116800 can be used for the research of myocardial infarction .
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