169799-04-6
Chemical Structure
CGS 27023A
- CAS No.: 169799-04-6
- Formula:C18H24ClN3O5S
- Molecular Weight:429.92
IUPAC Name: (R)-N-hydroxy-2-((4-methoxy-N-(pyridin-3-ylmethyl)phenyl)sulfonamido)-3-methylbutanamide hydrochloride
InChIKey: ZVYIZSNCEAHMCF-UNTBIKODSA-N
SMILES: CC(C)[C@@H](N(S(=O)(C1=CC=C(OC)C=C1)=O)CC2=CC=CN=C2)C(NO)=O.[H]Cl
Biological Activity: CGS 27023A is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A prevents cartilage degradation in stromelysin-induced rabbit cartilage degradation model. CGS 27023A can be used for study of arthritis[1].
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CGS 27023A | CGS 27023A is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A prevents cartilage degradation in stromelysin-induced rabbit cartilage degradation model. CGS 27023A can be used for study of arthritis. | |||||||||||||||||||||
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Keywords
