291533-11-4
Chemical Structure
PG 116800
Synonym(s): PG 530742; PGE 530742; PGE 7113313
- CAS No.: 291533-11-4
- Formula:C24H27N3O7S
- Molecular Weight:501.55
IUPAC Name: 2-((4-(4-methoxybenzamido)phenyl)sulfonamido)-6-morpholinohex-4-ynoic acid
InChIKey: JAYVKNDQKXUNOJ-UHFFFAOYSA-N
SMILES: OC(C(NS(=O)(C1=CC=C(NC(C2=CC=C(OC)C=C2)=O)C=C1)=O)CC#CCN3CCOCC3)=O
Biological Activity: PG 116800 (PGE 530742; PGE 7113313) is an orally active, selective and high-affinity inhibitor of MMP. PG 116800 acts as an inhibitor of ventricular remodeling, reduces left ventricular volumes and infarct zone collagen content, and improves ejection fraction. PG 116800 is generally well tolerated, but is associated with higher rates of arthralgia, joint stiffness, and dyspepsia. PG 116800 can be used for the research of myocardial infarction[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PG 116800 | 99.81% | PG 116800 (PGE 530742; PGE 7113313) is an orally active, selective and high-affinity inhibitor of MMP. PG 116800 acts as an inhibitor of ventricular remodeling, reduces left ventricular volumes and infarct zone collagen content, and improves ejection fraction. PG 116800 is generally well tolerated, but is associated with higher rates of arthralgia, joint stiffness, and dyspepsia. PG 116800 can be used for the research of myocardial infarction. | ||||||||||||||||||||
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- [1]. Krzeski P, et al. Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study. Arthritis Res Ther. 2007;9(5):R109. [Content Brief]
- [2]. Hudson MP, et al. Effects of selective matrix metalloproteinase inhibitor (PG-116800) to prevent ventricular remodeling after myocardial infarction: results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) trial. J Am Coll Cardiol. 2006 Jul 4;48(1):15-20. [Content Brief]
Keywords
