country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-N1034

Copy Link Print Information

12-Oxocalanolide A

Name: 12-Oxocalanolide A
Brand: MedChemExpress
SKU: HY-N1034
Availability: PreOrder

(Synonyms: (±)-12-Oxocalanolide A)

12-Oxocalanolide A (compound 6) is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1) with an IC₅₀ and EC₅₀ of 2.8 and 12 μM, respectively. 12-Oxocalanolide A is the analogue of Calanolide.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 161753-49-7
화학식: C₂₂H₂₄O₅
분자량:368.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

12-Oxocalanolide A Chemical Structure

CAS No.: 161753-49-7

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

HIV-1

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
AA5	EC₅₀	2.8 μM Compound: (+/-)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell	[PMID: 9873509]
B-cell	EC₅₀	>10 μM Compound: (+)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell	[PMID: 9873509]
CCRF-CEM	EC₅₀	1.09 μM Compound: (+)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS T-cells Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS T-cells	[PMID: 9873509]
CCRF-CEM	EC₅₀	>10 μM Compound: (+)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in 174 x CEM T-cell:B-cell fusion Compound was evaluated for the anti-HIV activity against HIV strain IIIB in 174 x CEM T-cell:B-cell fusion	[PMID: 9873509]
CEM-SS	EC₅₀	0.15 μM Compound: 10	Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]
CEM-SS	IC₅₀	9.3 μM Compound: 10	Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]
CEM-SS	EC₅₀	1.2 μM Compound: (+/-)5	Concentration required to protect CEM-SS cells from HIV-1 mediated cytopathicity by 50% relative to drug-free controls was determined Concentration required to protect CEM-SS cells from HIV-1 mediated cytopathicity by 50% relative to drug-free controls was determined	[PMID: 9083491]
CEM-SS	IC₅₀	19 μM Compound: (+/-)5	Antiviral activity against HIV-1 determined by concentration which resulted in cytotoxicity of 50% of CEM-SS cell population relative to drug-free controls Antiviral activity against HIV-1 determined by concentration which resulted in cytotoxicity of 50% of CEM-SS cell population relative to drug-free controls	[PMID: 9083491]
CEM-SS	EC₅₀	0.52 μM Compound: (+/-)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS Value was expressed as EC50 Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS Value was expressed as EC50	[PMID: 9873509]

Chemical Information

CAS No. 161753-49-7
분자량 368.42
화학식 C₂₂H₂₄O₅
SMILES

O=C1C=C(CCC)C2=C3C(C=CC(C)(C)O3)=C4C(C([C@H](C)[C@@H](C)O4)=O)=C2O1
Synonyms

(±)-12-Oxocalanolide A
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zembower DE, et al. Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C). J Med Chem. 1997;40(6):1005-1017. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기