3-Phosphoglyceric acid
Based on 1 Customer Validation
3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid is involved in alveolar macrophage epigenetic regulation.
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- Purity: 99.88%
- CAS No.: 820-11-1
- 화학식: C3H7O7P
- 분자량:186.06
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보관:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Biological Activity
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Human Endogenous Metabolite |
3-Phosphoglyceric acid (400 μM; 24 hours; BMDMs) treatment enhances Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification is also reversed[1].
3-Phosphoglyceric treatment significantly augmentes gene expression as well as H3K4me3 deposition of Spp1 in IL-4-stimulated macrophages[1].
In yeast, 3-Phosphoglyceric acid acts as a metabolic checkpoint for the formation of a multicomponent enzyme complex including serine metabolic enzymes and pyruvate kinase isoform 2 (PKM2) homologue, which senses both serine metabolism and glycolysis and regulates H3K4 methylation and histone phosphorylation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Bone marrow-derived macrophages (BMDMs)
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Concentration:400 µM
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Incubation Time:24 hours
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Result:Enhanced Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification was also reversed.
Chemical Information
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CAS No. 820-11-1
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Appearance Viscous Liquid
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분자량 186.06
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화학식 C3H7O7P
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Color Colorless to light yellow
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SMILES
O=C(O)C(O)COP(O)(O)=O
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Synonyms
3-PGA; 3-Glycerophosphoric acid
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
H2O : 100 mg/mL (537.46 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (271 KB)
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SDS (477 KB)
- English - EN (477 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.3746 mL | 26.8731 mL | 53.7461 mL | 134.3653 mL |
| 5 mM | 1.0749 mL | 5.3746 mL | 10.7492 mL | 26.8731 mL | |
| 10 mM | 0.5375 mL | 2.6873 mL | 5.3746 mL | 13.4365 mL | |
| 15 mM | 0.3583 mL | 1.7915 mL | 3.5831 mL | 8.9577 mL | |
| 20 mM | 0.2687 mL | 1.3437 mL | 2.6873 mL | 6.7183 mL | |
| 25 mM | 0.2150 mL | 1.0749 mL | 2.1498 mL | 5.3746 mL | |
| 30 mM | 0.1792 mL | 0.8958 mL | 1.7915 mL | 4.4788 mL | |
| 40 mM | 0.1344 mL | 0.6718 mL | 1.3437 mL | 3.3591 mL | |
| 50 mM | 0.1075 mL | 0.5375 mL | 1.0749 mL | 2.6873 mL | |
| 60 mM | 0.0896 mL | 0.4479 mL | 0.8958 mL | 2.2394 mL | |
| 80 mM | 0.0672 mL | 0.3359 mL | 0.6718 mL | 1.6796 mL | |
| 100 mM | 0.0537 mL | 0.2687 mL | 0.5375 mL | 1.3437 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
3-Phosphoglyceric acid Related Classifications
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