(S)-Willardiine
Based on 1 Customer Validation
(S)-Willardiine ((-)-Willardiine) is a subtype-selective glutamate receptor agonist and the active isomer of Willardiine. Willardiine binds to and activates hGluR1, hGluR2, hGluR4 and hGluR5, with Ki values of 3.6 nM and 0.24 nM for hGluR4 and hGluR5, respectively. (S)-Willardiine is used to investigate the distribution and physiological functions of glutamate receptor subunits in the central nervous system.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.93%
- CAS No.: 21416-43-3
- 화학식: C7H9N3O4
- 분자량:199.17
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All iGluR Isoforms
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Biological Activity
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AMPA Receptor |
Kainate Receptor |
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Cell Line
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Type | Value | Description | References |
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| Oocyte | EC50 |
11.5 μM
Compound: (S)-2a, (S)-willardiine
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Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method
Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method
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[PMID: 18811139] |
(S)-Willardiine (10-12-10-3 M; 60 min) binds with low affinity to homomeric hGluR1, hGluR2, and hGluR4 receptors, displaying the weakest potency among tested willardiine analogs on these human AMPA receptor subtypes[1].
(S)-Willardiine (10-12-10-3 M; 60 min) binds with very low affinity to homomeric hGluR5 receptors, displaying the weakest potency among tested willardiine analogs on this human kainate receptor subtype[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 21416-43-3
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Appearance Solid
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분자량 199.17
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화학식 C7H9N3O4
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Color White to off-white
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SMILES
N[C@@H](CN(C(N1)=O)C=CC1=O)C(O)=O
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Synonyms
(-)-Willardiine
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
용액&용해도
H2O : < 0.1 mg/mL (insoluble)
순도&문서
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-Willardiine Related Classifications
HY-12499 Related Classifications
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