COX-2-IN-59
COX-2-IN-59 is a potent and selective COX-2 inhibitor with an IC50 of 0.052 μM. COX-2-IN-59 exhibits 200-fold selectivity over COX-1 (IC50 = 11.16 μM). COX-2-IN-59 reduces COX-2 levels, induces cell cycle arrest, and triggers apoptosis by increasing Bax expression, decreasing Bcl-2 levels, and activating caspase-3. COX-2-IN-59 can be used for the research of colon cancer.
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- 화학식: C18H19N3O6S
- 분자량:405.42
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
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Biological Activity
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COX-2 0.052 μM (IC50) |
COX-1 11.16 μM (IC50) |
COX-2-IN-59 (compound 5d) (12.5-100 μM; 24 h) inhibits A-549, HOS, MCF‐7, HT‐29, PC3, and Caco‐2 cell growth with IC50s of 4, 67.3, 30.5, 8.5, 29.1, and 2.6 μM, respectively[1].
COX-2-IN-59 (2.6 μM; 24 h) induces G1/S cell cycle arrest, and triggers apoptosis in Caco-2 cells by increasing Bax expression, decreasing Bcl-2 levels, and activating caspase-3[1].
COX-2-IN-59 (2.6 μM; 24 h) significantly reduces COX-2 levels to 3.858 ng/mL (0.494‐fold relative to control) in Caco-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A-549, HOS, MCF-7, HT-29, PC3, and Caco-2 cells
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Concentration:12.5-100 μM
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Incubation Time:24 h
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Result:Inhibited A-549, HOS, MCF-7, HT-29, PC3, and Caco-2 cell growth with IC50s of 4, 67.3, 30.5, 8.5, 29.1, and 2.6 μM, respectively.
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Cell Line:Caco-2
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Concentration:2.6 μM
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Incubation Time:24 h
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Result:Demonstrated potent proapoptotic activity in Caco-2 cells, inducing a nearly eightfold increase in total apoptosis (24.38% vs. 3.16% in controls). Induced a dramatic 63-fold increase (15.86% vs. 0.25%) in late apoptosis, and an 11-fold increase (4.85% vs. 0.42%) in early apoptosis.
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Cell Line:Caco-2
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Concentration:2.6 μM
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Incubation Time:24 h
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Result:Showed a dramatic decrease in G2/M phase cells in the treated group (3.82%) compared to the control group (22.05%). Significantly increased cells in the G0/G1 phase (64.06% vs. 48.29% in control). Induced G1/S phase cell cycle arrest.
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Cell Line:Caco-2
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Concentration:2.6 μM
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Incubation Time:24 h
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Result:Induced the expression of Bax while suppressing the expression of Bcl‐2, ultimately leading to an increased expression of caspase‐3.
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Cell Line:Caco-2
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Concentration:2.6 μM
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Incubation Time:24 h
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Result:Significantly reduced COX-2 levels to 3.858 ng/mL (0.494‐fold relative to control).
Chemical Information
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분자량 405.42
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화학식 C18H19N3O6S
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SMILES
CC(NC1=CC=C(OCC(N/N=C/C2=CC=C(OS(=O)(C)=O)C=C2)=O)C=C1)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-2-IN-59 Related Classifications
HY-179125 Related Classifications
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