Erufosine
Erufosine is an inhibitor of PI3K/Akt and Ras/Raf/MAPK signaling pathways. Erufosine inhibits the activity of breast cancer cell lines MCF-7 and MDA-MB 231 (IC50: 40.95/40.8 μM). Erufosine reduces the phosphorylation of PI3K (p85), Akt (PKB), and cRaf. Erufosine can be used in the study of breast cancer and myeloid leukemia.
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- CAS No.: 202867-33-2
- 화학식: C28H58NO4P
- 분자량:503.74
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | CC50 |
28 μM
Compound: Erufosine
|
Cytotoxicity against human HEK293T cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
Cytotoxicity against human HEK293T cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
|
[PMID: 36827952] |
| THP-1 | CC50 |
2 μM
Compound: Erufosine
|
Cytotoxicity against human THP-1 cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
Cytotoxicity against human THP-1 cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
|
[PMID: 36827952] |
Chemical Information
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CAS No. 202867-33-2
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분자량 503.74
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화학식 C28H58NO4P
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SMILES
CCCCCCCC/C=C\CCCCCCCCCCCCOP(OCCC[N+](C)(C)C)([O-])=O
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Synonyms
ErPC3; Erucylphosphohomocholine
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선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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