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PCP2 - Purkinje cell protein 2 Gene

Also Known as PCD5; GPSM4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 126006

About PCP2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,631,615-7,637,006 (from NCBI)

This gene has 2 transcripts (splice variants) and 105 orthologues. Biased expression in testis (RPKM 11.4), salivary gland (RPKM 2.1) and 8 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity. Predicted to act upstream of or within rhodopsin mediated signaling pathway. Predicted to be located in neuronal cell body. [provided by Alliance of Genome Resources, Apr 2022]

PCP2 Products (2)

mRNA	Protein	Name
NM_001271830.2	NP_001258759.1	Purkinje cell protein 2 homolog isoform 2
NM_174895.3	NP_777555.1	Purkinje cell protein 2 homolog isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCP2 Protein Structure

GoLoco

0
100
136 a.a.

Protein Preferred Names	Protein Names
Purkinje cell protein 2 homolog	CTD-3214H19.6

PCP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PCP2	Q8IVA1	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	PCP2	Q8IVA1	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	PCP2	Q8IVA1	GNAI2	Homo sapiens	P04899	Y2H Array	32296183
Intra	PCP2	Q8IVA1	GNAI2	Homo sapiens	P04899	Y2H Prey Pooling	32296183
Intra	PCP2	Q8IVA1	GNAI3	Homo sapiens	P08754	Y2H Prey Pooling	32296183
Intra	PCP2	Q8IVA1	GNAI3	Homo sapiens	P08754	Anti Tag CoIP	28514442
Intra	PCP2	Q8IVA1	GNAI3	Homo sapiens	P08754	Y2H Array	32296183
Intra	PCP2	Q8IVA1	GNAI1	Homo sapiens	P63096	Y2H Array	32296183
Intra	PCP2	Q8IVA1	GNAI1	Homo sapiens	P63096	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Atrial Tachyarrhythmia With Short Pr Interval	Lown-Ganong-Levine Syndrome Syndrome Of Short P-R Interval, Normal Qrs Complexes, And Supraventricular Tachycardias Lgl Syndrome
Gaucher Disease, Type Iiic	Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome Gaucher-Like Disease GD3C Gaucher'S Disease Type Iiic Cardiovascular Gaucher Disease Gaucher Disease Type 3c Gaucher Disease 3c Pseudo-Gaucher Disease
Gaucher Disease, Type Iii	Gaucher Disease, Subacute Neuronopathic Type Gd Iii Gaucher Disease, Chronic Neuronopathic Type Gaucher Disease, Juvenile And Adult, Cerebral Gaucher Disease Type 3 GD3 Gaucher'S Disease Type Iii Gaucher Disease Type Iii Gd 3 Cerebral Juvenile And Adult Form Of Gaucher Disease Chronic Neuronopathic Gaucher Disease Gaucher Disease 3 Cerebral, Juvenile And Adult, Gaucher Disease Gaucher Disease Chronic Neuronopathic Type Gaucher Disease Type Ii Subacute Neuronopathic Gaucher Disease Type 3 Gaucher Disease Gaucher Disease, Type 3 Gaucher Disease, Type 2
Spinocerebellar Ataxia 1	Spinocerebellar Ataxia Type 1 SCA1 Olivopontocerebellar Atrophy I Opca1 Opca4 Menzel Type Opca Schut-Haymaker Type Opca Spinocerebellar Atrophy I Opca I Olivopontocerebellar Atrophy Iv Opca Iv Cerebelloparenchymal Disorder I Cpd1 Olivopontocerebellar Atrophy 1 Cerebelloparenchymal Disorder 1 Olivopontocerebellar Atrophy 4 Spinocerebellar Atrophy 1 Type 1 Spinocerebellar Ataxia Spinocerebellar Ataxia-1 Ataxia, Spinocerebellar, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS01533	BMP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10167	PCP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11451	PTPRU Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20321	Pcp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26829	Pcp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PCP2	RGD	RGD:1306217
Bos taurus	PCP2	VGNC	VGNC:32644
Canis familiaris	PCP2	VGNC	VGNC:44318
Mus musculus	PCP2	MGD	MGI:97508
Felis catus	PCP2	VGNC	VGNC:64072
Macaca mulatta	PCP2	VGNC	VGNC:75706
Others	PCP2	NCBI