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Cat. No.: HY-189248

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HK262

HK262 is a METTL21A inhibitor, with an IC₅₀ of 1.10 μM against human METTL21A. HK262 reduces the enzymatic activity of the protein lysine methyltransferase METTL21A. HK262 can be used in studies of hepatocellular carcinoma.

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화학식: C₁₆H₁₅F₅N₆O₄S
분자량:482.39

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

HK262 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

METTL21A

1.10 μM (IC₅₀)

All Histone Methyltransferase Isoforms :

In Vitro

HK262 (compound 6n) is the most potent METTL21A inhibitor identified in this series, with an IC₅₀ of 1.10 μM for the purified recombinant human METTL21A enzyme^[1].
HK262 (100 μM; 2 h) displays favorable kinetic solubility of 85 μM in pH 7.4 phosphate-buffered saline^[1].
HK262 (120 min) exhibits high stability in both human and mouse plasma following 120 min of incubation^[1].
HK262 (45 min) displays high metabolic stability in vitro in both human liver microsomes and mouse liver microsomes after 45 min of incubation^[1].
HK262 (10 μM; 72 h) does not reduce the viability of HepG2 cells after 72 h of exposure at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HepG2 cells
Concentration:

10 μM
Incubation Time:

72 h
Result:

Resulted in HepG2 cell viability of 102% of the untreated control value after 72 h of exposure, with no observable reduction in cell viability.

Chemical Information

분자량 482.39
화학식 C₁₆H₁₅F₅N₆O₄S
SMILES

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(N)N=CN=C23)O[C@@H]1C(NC4=CC=C(S(F)(F)(F)(F)F)C=C4)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Kocek H, et al. First-in-class inhibitors of the protein lysine methyltransferase METTL21A. European journal of medicinal chemistry. 2026 Aug 11;319:119227.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

HK262

All Histone Methyltransferase Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

HK262 Related Classifications

HY-189248 Related Classifications

Bioz

Keywords

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