Nidanilimab (Nadunolimab)
Based on 1 Customer Validation
Nidanilimab (CAN04) is a fully humanized monoclonal anti-IL1RAP antibody with a Kd value of 1.10 pM. Nidanilimab blocks IL1α and IL1β signaling and stimulates the immune system to destroy tumour cells. Nidanilimab can be used in research of non-small lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) .
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- Purity: 99.90%
- CAS No.: 2171061-85-9
- 분자량:144.3 kDa
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Human IgG1 kappa
Human
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IL-1α |
IL-1β |
Nidanilimab (CAN04; 20 µg/mL; murine MC38 colon cancer cells) has glycoengineered to mediate an enhanced antibody-dependent cellular cytotoxicity (ADCC, EC50<1 nM)[2].
Nidanilimab (20 µg/mL; murine MC38 colon cancer cells) blocks IL1α and IL1β signaling with IC50 values of 3.9 nM and 4.1 nM, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude C57Bl/6 mice with LU2503 NSCLC PDX model[1]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection
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Result:Displayed a significantly stronger anti-tumor effect compared to isotype control with chemotherapy.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized Human IL1RAP/IL-1RAcP Protein (His Tag) can bind Nidanilimab. The EC50 for this effect is 1.80 ng/mL. -
Loaded Nidanilimab (Nadunolimab) on AHC2 biosensor, can bind IL-1RAcP/IL-1 R3 Protein, Human (339a.a, HEK293, His, HY-P72565) with an affinity constant of 5.812E-10 M as determined in BLI assay.
Chemical Information
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CAS No. 2171061-85-9
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Appearance Liquid
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분자량 144.3 kDa
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Color Colorless to light yellow
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SMILES
[Nidanilimab (Nadunolimab)]
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Synonyms
CAN04; Anti-IL-1RAP/IL-1R3 Reference Antibody (nidanilimab)
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (261 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nidanilimab (Nadunolimab) Related Classifications
HY-P99379 Related Classifications
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