IL1RAP - interleukin 1 receptor accessory protein Gene

Homo sapiens

Also known as IL1R3; C3orf13; IL-1RAcP

Gene ID: 3556 | Gene type: protein coding

About IL1RAP

Cytogenetic location: 3q28 Genomic coordinates (GRCh38): 3:190,514,085-190,659,750 (from NCBI)

This gene has 19 transcripts (splice variants), 199 orthologues and 10 paralogues. Broad expression in liver (RPKM 11.2), placenta (RPKM 7.8) and 21 other tissues.

Summary

This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018]

IL1RAP Products(9)

mRNA	Protein	Name
NM_001167928.2	NP_001161400.1	interleukin-1 receptor accessory protein isoform 1 precursor
NM_001167929.2	NP_001161401.1	interleukin-1 receptor accessory protein isoform 1 precursor
NM_001167930.2	NP_001161402.1	interleukin-1 receptor accessory protein isoform 2 precursor
NM_001167931.2	NP_001161403.1	interleukin-1 receptor accessory protein isoform 3 precursor
NM_001364879.1	NP_001351808.1	interleukin-1 receptor accessory protein isoform 3 precursor
NM_001364880.2	NP_001351809.1	interleukin-1 receptor accessory protein isoform 4 precursor
NM_001364881.2	NP_001351810.1	interleukin-1 receptor accessory protein isoform 1 precursor
NM_002182.4	NP_002173.1	interleukin-1 receptor accessory protein isoform 1 precursor
NM_134470.4	NP_608273.1	interleukin-1 receptor accessory protein isoform 2 precursor

IL1RAP Protein Structure

Ig_2

TIR

0
100
200
300
400
500
570 a.a.

Protein Preferred Names

Protein Names

interleukin-1 receptor accessory protein

IL-1 receptor accessory protein

Recombinant IL1RAP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72565	IL-1RAcP/IL-1 R3 Protein, Human (339a.a, HEK293, His)	Q9NPH3 (S21-E359)	≥95%
HY-P77413	IL-1RAcP/IL-1 R3 Protein, Human (HEK293, Fc)	Q9NPH3-1 (S21-E359)	≥95%
HY-P77414	IL-1RAcP/IL-1 R3 Protein, Human (Biotinylated, HEK 293, His-Avi)	Q9NPH3 (M1-E359)	≥95%
HY-P77415	IL-1RAcP/IL-1 R3 Protein, Human (HEK293, His-Fc)	Q9NPH3 (M1-E359)	≥95%
HY-P77416	IL-1RAcP/IL-1 R3 Protein, Human (359a.a, HEK293, His)	Q9NPH3 (M1-E359)	≥95%
HY-P78146	IL-1RAcP/IL-1 R3 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9NPH3 (S21-E359)	≥95%
HY-P78463	IL-1RAcP/IL-1 R3 Protein, Human (HEK293, His-Avi)	Q9NPH3 (S21-E359)	≥95%

Related Diseases

Diseases

Alias

Indolent Plasma Cell Myeloma

Indolent Myeloma

Indolent Multiple Myeloma

Chromosome Xp21 Deletion Syndrome

Complex Glycerol Kinase Deficiency	Xp21 Microdeletion Syndrome
Monosomy Xp21	Xp21 Deletion Syndrome
Complex Gkd	Del
Xp21 Contiguous Gene Deletion Syndrome	Glycerol Kinase Deficiency - Contiguous Gene Syndrome

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99379	Nidanilimab	Inhibitor	99.90%	Phase 2
HY-P99235	Nadunolimab	Inhibitor	98.11%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06722	IL1RAP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IL1RAP	RGD	RGD:2893
Macaca mulatta	IL1RAP	VGNC	VGNC:73718
Felis catus	IL1RAP	VGNC	VGNC:97465
Mus musculus	IL1RAP	MGD	MGI:104975
Canis familiaris	IL1RAP	VGNC	VGNC:41960
Bos taurus	IL1RAP	VGNC	VGNC:30133
Macaca fascicularis	IL1RAP	NCBI
Others	IL1RAP	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.