IL1RAP - interleukin 1 receptor accessory protein Gene

Also Known as IL1R3; C3orf13; IL-1RAcP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3556

About IL1RAP

Cytogenetic location: 3q28 Genomic coordinates (GRCh38): 3:190,514,085-190,659,750 (from NCBI)

This gene has 19 transcripts (splice variants), 199 orthologues and 10 paralogues. Broad expression in liver (RPKM 11.2), placenta (RPKM 7.8) and 21 other tissues.

Summary

This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018]

IL1RAP Products (9)

mRNA Protein Name
NM_001167928.2 NP_001161400.1 interleukin-1 receptor accessory protein isoform 1 precursor
NM_001167929.2 NP_001161401.1 interleukin-1 receptor accessory protein isoform 1 precursor
NM_001167930.2 NP_001161402.1 interleukin-1 receptor accessory protein isoform 2 precursor
NM_001167931.2 NP_001161403.1 interleukin-1 receptor accessory protein isoform 3 precursor
NM_001364879.1 NP_001351808.1 interleukin-1 receptor accessory protein isoform 3 precursor
NM_001364880.2 NP_001351809.1 interleukin-1 receptor accessory protein isoform 4 precursor
NM_001364881.2 NP_001351810.1 interleukin-1 receptor accessory protein isoform 1 precursor
NM_002182.4 NP_002173.1 interleukin-1 receptor accessory protein isoform 1 precursor
NM_134470.4 NP_608273.1 interleukin-1 receptor accessory protein isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables coreceptor activity IDA
IDA: Inferred from direct assay
10854325 GOA
Biological Process GO Annotation Evidence References Source
involved in interleukin-1-mediated signaling pathway IDA
IDA: Inferred from direct assay
9065432 GOA
involved in interleukin-33-mediated signaling pathway IDA
IDA: Inferred from direct assay
17675517 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL1RAP Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (85 - 122)

Ig_2

Ig_2: Immunoglobulin domain (158 - 233)

TIR

TIR: TIR domain (408 - 544)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 570 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor accessory protein

  • IL-1 receptor accessory protein

Recombinant IL1RAP Proteins

Cat. No. Product Name Accession Purity
HY-P72565 IL-1RAcP/IL-1 R3 Protein, Human (HEK293, His) Q9NPH3-1 (S21-E359) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77413 IL-1RAcP/IL-1 R3 Protein, Human (HEK293, Fc) Q9NPH3-1 (S21-E359) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78146 IL-1RAcP/IL-1 R3 Protein, Human (Biotinylated, HEK293, His-Avi) Q9NPH3-1 (S21-E359) ≥ 95%, as determined by Bis-Tris PAGE.

IL1RAP Antibodies

Cat. No. Product Name Application Reactivity
HY-P83269 IL-1 Receptor Accessory Protein Antibody (YA3014) WB, IP, FC Human
HY-P83269A IL-1 Receptor Accessory Protein Antibody (YA3014)(PBS only) WB, IP, FC Human

Related Diseases

Diseases Alias
Indolent Plasma Cell Myeloma

  • Indolent Myeloma

  • Indolent Multiple Myeloma
Chromosome Xp21 Deletion Syndrome

  • Complex Glycerol Kinase Deficiency

  • Xp21 Microdeletion Syndrome

  • Monosomy Xp21

  • Xp21 Deletion Syndrome

  • Complex Gkd

  • Del

  • Xp21 Contiguous Gene Deletion Syndrome

  • Glycerol Kinase Deficiency - Contiguous Gene Syndrome
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99379 Nidanilimab (Nadunolimab) Inhibitor 99.90% Phase 2
HY-P991267 CAN10 Inhibitor 95.04% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06722 IL1RAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24078 Il1rap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17618 Il1rap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992026 ADV-101 Antibody / Unkown
HY-P992027 CSC012 Antibidy / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IL1RAP RGD RGD:2893
Macaca mulatta IL1RAP VGNC VGNC:73718
Felis catus IL1RAP VGNC VGNC:97465
Mus musculus IL1RAP MGD MGI:104975
Canis familiaris IL1RAP VGNC VGNC:41960
Bos taurus IL1RAP VGNC VGNC:30133
Others IL1RAP NCBI