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Cat. No.: HY-P99721

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Biologically Validated

Lutikizumab

(Synonyms: ABT-981)

Customer Review

Based on 1 Customer Validation

Lutikizumab (ABT-981) is an anti-IL-1α and IL-1β dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis.

For research use only. We do not sell to patients.

Purity: 96.54%
CAS No.: 1791411-57-8
Molecular Weight:196.57 kDa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Lutikizumab Chemical Structure

CAS No.: 1791411-57-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Isotype

[VH-VH'-H-Gamma1_VL-VL'-C-kappa]-dimer

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

IL-1a & IL1b

All Interleukin Related Isoforms :

In Vitro

ABT-981 shows simultaneously binding efficacy human IL-α and IL-1β molecules^[1].
ABT-981 shows highly specific binding effects to IL-α and IL-1β over other IL-1 family members^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lutikizumab (0.0001-1 mg/kg, i.p., once) shows effective inhibition to the IL-6 production induced by IL-1α and IL-1β^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female C57/BL6 mice with IL-1α and IL-1β injection^[1]
Dosage:

0.0001-1 mg/kg
Administration:

Intraperitoneal injection, 0.0001-1 mg/kg, once
Result:

Dose-dependently decreased the murine IL-6 generated by human and cynomolgus IL-1α and IL-1β.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

3552 [NCBI] & 3553 [NCBI]

Accession

P01583 & P01584

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

[VH-VH'-H-Gamma1_VL-VL'-C-kappa]-dimer

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Human IL-1 alpha/IL1A Protein can bind Lutikizumab. The EC₅₀ for this effect is 1.97 ng/mL.
Immobilized Human IL-1 beta Protein can bind Lutikizumab. The EC₅₀ for this effect is 3.63 ng/mL.

Chemical Information

CAS No. 1791411-57-8
Appearance Liquid
Molecular Weight 196.57 kDa
Color Colorless to light yellow
SMILES

[Lutikizumab]
Synonyms

ABT-981
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Lacy SE, et al. Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β. MAbs. 2015;7(3):605-19. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Purity & Documentation
References

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[VH-VH'-H-Gamma1_VL-VL'-C-kappa]-dimer
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Immobilized Human IL-1 alpha/IL1A Protein can bind Lutikizumab. The EC₅₀ for this effect is 1.97 ng/mL.
1/16

Immobilized Human IL-1 beta Protein can bind Lutikizumab. The EC₅₀ for this effect is 3.63 ng/mL.
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Lutikizumab

Cell-ATP Viability Detection Kit

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

Bradford Protein Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Antibody Inhibitor Library

All Interleukin Related Isoforms