Olanzapine-d3
Based on 1 Customer Validation
Olanzapine-d3 (LY170053-d3) is the deuterium labeled Olanzapine. Olanzapine is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic.
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- Purity: 98.57%
- CAS No.: 786686-79-1
- 화학식: C17H17D3N4S
- 분자량:315.45
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All 5-HT Receptor Isoforms
MoreAll Dopamine Receptor Isoforms
MoreAll Adrenergic Receptor Isoforms
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Biological Activity
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D3 Receptor |
mAChR1 |
5-HT2A Receptor |
5-HT6 Receptor |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 786686-79-1
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Unlabeled Cas 132539-06-1
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Appearance Solid
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분자량 315.45
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화학식 C17H17D3N4S
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Color White to yellow
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SMILES
[2H]C(N1CCN(C2=NC3=CC=CC=C3NC4=C2C=C(C)S4)CC1)([2H])[2H]
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Synonyms
LY170053-d3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 20 mg/mL (63.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1701 mL | 15.8504 mL | 31.7007 mL | 79.2519 mL |
| 5 mM | 0.6340 mL | 3.1701 mL | 6.3401 mL | 15.8504 mL | |
| 10 mM | 0.3170 mL | 1.5850 mL | 3.1701 mL | 7.9252 mL | |
| 15 mM | 0.2113 mL | 1.0567 mL | 2.1134 mL | 5.2835 mL | |
| 20 mM | 0.1585 mL | 0.7925 mL | 1.5850 mL | 3.9626 mL | |
| 25 mM | 0.1268 mL | 0.6340 mL | 1.2680 mL | 3.1701 mL | |
| 30 mM | 0.1057 mL | 0.5283 mL | 1.0567 mL | 2.6417 mL | |
| 40 mM | 0.0793 mL | 0.3963 mL | 0.7925 mL | 1.9813 mL | |
| 50 mM | 0.0634 mL | 0.3170 mL | 0.6340 mL | 1.5850 mL | |
| 60 mM | 0.0528 mL | 0.2642 mL | 0.5283 mL | 1.3209 mL |
Olanzapine-d3 Related Classifications
HY-14541S Related Classifications
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