Oxiran-2-ylmethanol
Based on 1 Customer Validation
Oxiran-2-ylmethanol (Glycidol) is an ester product. Oxiran-2-ylmethanol induces base pair point mutations in bacterial strains and structural chromosome aberrations in cultured cells. Oxiran-2-ylmethanol forms N-(2,3-dihydroxypropyl)valine hemoglobin adducts. Oxiran-2-ylmethanol acts as an animal carcinogen but does not significantly induce micronucleated immature erythrocytes in animal bone marrow. Oxiran-2-ylmethanol enables anionic polymerization to produce linear poly(glycidol). Oxiran-2-ylmethanol can be used for cancer-related research.
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- Purity : 99.95%
- CAS No.: 556-52-5
- 화학식: C3H6O2
- 분자량:74.08
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보관:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
Oxiran-2-ylmethanol (G) (0.31-5000 μg/plate; 48 h) induces dose-dependent reverse mutations in Salmonella typhimurium (TA98, TA100, TA1535, TA1537) and Escherichia coli (WP2uvrA) strains, with particularly strong activity in point mutation-detecting strains, in both the presence and absence of metabolic activation[1].
Oxiran-2-ylmethanol induces structural chromosomal aberrations in cultured Chinese hamster lung (CHL/IU) cells under short-term (with and without metabolic activation) and continuous (24 h and 48 h) treatment conditions, with the highest aberration frequency reaching 93.5% at 300 μg/mL in 6 h treatment without metabolic activation[1].
Oxiran-2-ylmethanol (125-250 μM; 1 h at 37 °C) forms N-(2,3-dihydroxypropyl)valine adducts with hemoglobin in fresh human whole blood with a second-order reaction rate constant of 19.2 pmol/g Hb per µMh[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 556-52-5
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Appearance Liquid (Density: 1.115 g/cm3)
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분자량 74.08
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화학식 C3H6O2
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Color Colorless to light yellow
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SMILES
OCC1OC1
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Synonyms
Glycidol
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 100 mg/mL (1349.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (67.49 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (67.49 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (272 KB)
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SDS (799 KB)
- English - EN (799 KB)
- Français - FR (799 KB)
- Deutsch - DE (799 KB)
- Norwegian - NO (799 KB)
- Español - ES (799 KB)
- Swedish - SV (799 KB)
- Italian - IT (799 KB)
- Korean - KR (799 KB)
- Portuguese - PT (799 KB)
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Handling Instructions (2659 KB)
References
[1]. Ikeda N, et al. Genotoxicity studies of glycidol fatty acid ester (glycidol linoleate) and glycidol. Food Chem Toxicol. 2012;50(11):3927-3933. [Content Brief]
[2]. Stichler S, et al. Thiol-ene Clickable Poly(glycidol) Hydrogels for Biofabrication. Ann Biomed Eng. 2017;45(1):273-285. [Content Brief]
[3]. Aasa J, et al. Internal Doses of Glycidol in Children and Estimation of Associated Cancer Risk. Toxics. 2019;7(1):7. Published 2019 Feb 1. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 13.4989 mL | 67.4946 mL | 134.9892 mL | 337.4730 mL |
| 5 mM | 2.6998 mL | 13.4989 mL | 26.9978 mL | 67.4946 mL | |
| 10 mM | 1.3499 mL | 6.7495 mL | 13.4989 mL | 33.7473 mL | |
| 15 mM | 0.8999 mL | 4.4996 mL | 8.9993 mL | 22.4982 mL | |
| 20 mM | 0.6749 mL | 3.3747 mL | 6.7495 mL | 16.8736 mL | |
| 25 mM | 0.5400 mL | 2.6998 mL | 5.3996 mL | 13.4989 mL | |
| 30 mM | 0.4500 mL | 2.2498 mL | 4.4996 mL | 11.2491 mL | |
| 40 mM | 0.3375 mL | 1.6874 mL | 3.3747 mL | 8.4368 mL | |
| 50 mM | 0.2700 mL | 1.3499 mL | 2.6998 mL | 6.7495 mL | |
| 60 mM | 0.2250 mL | 1.1249 mL | 2.2498 mL | 5.6245 mL | |
| 80 mM | 0.1687 mL | 0.8437 mL | 1.6874 mL | 4.2184 mL | |
| 100 mM | 0.1350 mL | 0.6749 mL | 1.3499 mL | 3.3747 mL |
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