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Cat. No.: HY-134636

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PAPA NONOate

Name: PAPA NONOate
Brand: MedChemExpress
SKU: HY-134636
Price: 50.00 USD
Availability: InStock
Rating: 5 (2 reviews)

2 Cited Publications

고객리뷰

Based on 2 publication(s) in Google Scholar

PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 98.0%
CAS No.: 146672-58-4
화학식: C₆H₁₆N₄O₂
분자량:176.22

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

PAPA NONOate Chemical Structure

CAS No.: 146672-58-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
Publications (2)
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Endogenous Metabolite Isoforms :

In Vitro

PAPA NONOate (50 μM; 12 h) significantly reduces 70% caspase-3-like activity in caspase-3-overexpressing HUVEC and abolishs the induction of cell death by caspase-3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound^[2]
Dosage:

100 μM
Administration:

Wounds received 100 μM PAPA NONOate in phosphate buffer
Result:

Increased the wound healing rate in test group.

Chemical Information

CAS No. 146672-58-4
Appearance Solid
분자량 176.22
화학식 C₆H₁₆N₄O₂
Color White to light yellow
SMILES

NCCCN(CCC)N(O)N=O
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Endogenous metabolite
선적

Shipping with dry ice.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

ACS Nano

Triple-Cascade Responsive Pneumatic Nanomotor Enhance Cancer Immunotherapy by Oncolytic Virus-Triggered Pyroptosis. [Abstract]

2026 Mar 31;20(12):9784-9801. PMID: 41842752
Neurosci Bull

Targeting Phospholipid Metabolism as an Effective Hearing Protection Strategy. [Abstract]

2025 Jun 28. PMID: 40580390

용액&용해도

In Vitro:

H₂O : 50 mg/mL (283.74 mM; ultrasonic and warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.6747 mL

28.3736 mL

56.7472 mL

5 mM

1.1349 mL

5.6747 mL

11.3494 mL

10 mM

0.5675 mL

2.8374 mL

5.6747 mL

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rössig L, et al. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem. 1999 Mar 12;274(11):6823-6. [Content Brief]

[2]. N Dashti, et al. Study of the effect of PAPA NONOate on the rate of diabetic wound healing. African Journal of Biotechnology. 2014.

[3]. Keefer LK, et al. "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. Methods Enzymol. 1996;268:281-93. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	5.6747 mL	28.3736 mL	56.7472 mL	141.8681 mL
	5 mM	1.1349 mL	5.6747 mL	11.3494 mL	28.3736 mL
	10 mM	0.5675 mL	2.8374 mL	5.6747 mL	14.1868 mL
	15 mM	0.3783 mL	1.8916 mL	3.7831 mL	9.4579 mL
	20 mM	0.2837 mL	1.4187 mL	2.8374 mL	7.0934 mL
	25 mM	0.2270 mL	1.1349 mL	2.2699 mL	5.6747 mL
	30 mM	0.1892 mL	0.9458 mL	1.8916 mL	4.7289 mL
	40 mM	0.1419 mL	0.7093 mL	1.4187 mL	3.5467 mL
	50 mM	0.1135 mL	0.5675 mL	1.1349 mL	2.8374 mL
	60 mM	0.0946 mL	0.4729 mL	0.9458 mL	2.3645 mL
	80 mM	0.0709 mL	0.3547 mL	0.7093 mL	1.7734 mL
	100 mM	0.0567 mL	0.2837 mL	0.5675 mL	1.4187 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bioz

Keywords

PAPA NONOate

2 Cited Publications

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Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
Publications (2)
용액&용해도
- In Vitro
순도&문서
References

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PAPA NONOate

Publications Citing Use of MedChemExpress (MCE) PAPA NONOate

All Endogenous Metabolite Isoforms