Sodium mercaptopyruvate
Based on 1 Customer Validation
Sodium mercaptopyruvate serves as a substrate for Lactate dehydrogenase and Sulfurtransferase. Sodium mercaptopyruvate forms through enzymatic transamination and oxidative deamination of L-cysteine (HY-Y0337). Sodium mercaptopyruvate abolishes lactate dehydrogenase reaction activity. It increases urinary thiosulfate excretion, fails to sustain rat growth by replacing L-cystine (HY-N0394), and does not induce morbidity or mortality in mice. Sodium mercaptopyruvate is applicable to research related to 3-mercaptopyruvate disulfiduria and 3-mercaptolactate disulfiduria.
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- CAS No.: 10255-67-1
- 화학식: C3H3NaO3S
- 분자량:142.11
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보관:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Biological Activity
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Chemical Information
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- References
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Biological Activity
Sodium mercaptopyruvate serves as an excellent substrate for bovine heart lactate dehydrogenase, and supports rapid stoichiometric NADH oxidation within 5 min[1].
Sodium mercaptopyruvate (5-10 mM; up to 4 h) loses lactate dehydrogenase reaction activity over time under neutral pH conditions: at pH 7.0 and 25°C, 50% of its activity is lost at approximately 80 minutes, and its stability increases at lower pH values[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male mice (23-25 g body weight)[1]
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Dosage:7 μmol/g body weight; 100 mM (72-hour incubated form)
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Administration:Injection; single dose
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Result:Showed no morbidity or mortality in four mice over a 48-hour observation period.
Showed no morbidity or mortality in eight male mice over the observation period when injected with the 72-hour incubated 100 mM form.
Chemical Information
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CAS No. 10255-67-1
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Appearance Solid
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분자량 142.11
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화학식 C3H3NaO3S
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Color White to light yellow
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SMILES
O=C(C(CS)=O)O[Na]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
순도&문서
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Data Sheet (270 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sodium mercaptopyruvate Related Classifications
HY-W170255 Related Classifications
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- Sodium mercaptopyruvate
- 10255-67-1
- Lactate Dehydrogenase
- Drug Derivative
- tRNA sulfurtransferase
- 3-mercaptopyruvate desulfurase
- rat
- 3-mercaptolactate disulfiduria
- 3-mercaptopyruvate disulfiduria
- L-cysteine
- mice
- lactate dehydrogenase
- glutamine transaminase
- 3-mercaptopyruvate sulfurtransferase
- Inhibitor
- inhibitor
- inhibit