10255-67-1
Chemical Structure
Sodium mercaptopyruvate
- CAS No.: 10255-67-1
- Formula:C3H3NaO3S
- Molecular Weight:142.11
IUPAC Name: sodium 3-mercapto-2-oxopropanoate
InChIKey: CODUSAVZTZYYDD-UHFFFAOYSA-M
SMILES: O=C(C(CS)=O)O[Na]
Biological Activity: Sodium mercaptopyruvate serves as a substrate for Lactate dehydrogenase and Sulfurtransferase. Sodium mercaptopyruvate forms through enzymatic transamination and oxidative deamination of L-cysteine (HY-Y0337). Sodium mercaptopyruvate abolishes lactate dehydrogenase reaction activity. It increases urinary thiosulfate excretion, fails to sustain rat growth by replacing L-cystine (HY-N0394), and does not induce morbidity or mortality in mice. Sodium mercaptopyruvate is applicable to research related to 3-mercaptopyruvate disulfiduria and 3-mercaptolactate disulfiduria[1][2].
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Sodium mercaptopyruvate | Sodium mercaptopyruvate serves as a substrate for Lactate dehydrogenase and Sulfurtransferase. Sodium mercaptopyruvate forms through enzymatic transamination and oxidative deamination of L-cysteine (HY-Y0337). Sodium mercaptopyruvate abolishes lactate dehydrogenase reaction activity. It increases urinary thiosulfate excretion, fails to sustain rat growth by replacing L-cystine (HY-N0394), and does not induce morbidity or mortality in mice. Sodium mercaptopyruvate is applicable to research related to 3-mercaptopyruvate disulfiduria and 3-mercaptolactate disulfiduria. | |||||||||||||||||||||
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- [1]. Cooper AJ, et al. On the chemistry and biochemistry of 3-mercaptopyruvic acid, the alpha-keto acid analog of cysteine. J Biol Chem. 1982 Jan 25;257(2):816-26. PMID: 7054184. [Content Brief]
- [2]. TANABE S, et al. Preparation of a sulfurtransferase substrate, sodium 3-mercaptopyruvate, from 3-bromopyruvic acid and sodium hydrosulfide[J]. Chemical and pharmaceutical bulletin, 1989, 37(10): 2843-2845.
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