Sodium mercaptopyruvate

Name: Sodium mercaptopyruvate
Brand: MedChemExpress
SKU: HY-W170255
Rating: 4.5 (0 reviews)

Cat. No.: HY-W170255: Data Sheet
COA

SDS
Handling Instructions
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Sodium mercaptopyruvate serves as a substrate for Lactate dehydrogenase and Sulfurtransferase. Sodium mercaptopyruvate forms through enzymatic transamination and oxidative deamination of L-cysteine (HY-Y0337). Sodium mercaptopyruvate abolishes lactate dehydrogenase reaction activity. It increases urinary thiosulfate excretion, fails to sustain rat growth by replacing L-cystine (HY-N0394), and does not induce morbidity or mortality in mice. Sodium mercaptopyruvate is applicable to research related to 3-mercaptopyruvate disulfiduria and 3-mercaptolactate disulfiduria.

For research use only. We do not sell to patients.

Sodium mercaptopyruvate Chemical Structure

CAS No. : 10255-67-1

Size	Stock	Quantity
Free Sample (0.1 - 0.2 mg)	Apply Now
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Purity & Documentation
References
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Description

In Vitro

Sodium mercaptopyruvate serves as an excellent substrate for bovine heart lactate dehydrogenase, and supports rapid stoichiometric NADH oxidation within 5 min^[1].
Sodium mercaptopyruvate (5-10 mM; up to 4 h) loses lactate dehydrogenase reaction activity over time under neutral pH conditions: at pH 7.0 and 25°C, 50% of its activity is lost at approximately 80 minutes, and its stability increases at lower pH values^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sodium mercaptopyruvate (7 μmol/g; 100 mM; administered via injection; single dose) does not cause morbidity or mortality in male mice within 48 h, nor does the aldol dimer formed after 72 h of incubation produce such effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male mice (23-25 g body weight)^[1]
Dosage:	7 μmol/g body weight; 100 mM (72-hour incubated form)
Administration:	Injection; single dose
Result:	Showed no morbidity or mortality in four mice over a 48-hour observation period. Showed no morbidity or mortality in eight male mice over the observation period when injected with the 72-hour incubated 100 mM form.

Molecular Weight

142.11

Formula

C₃H₃NaO₃S

CAS No.

10255-67-1

Appearance

Solid

Color

White to light yellow

SMILES

O=C(C(CS)=O)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

H₂O : 12.5 mg/mL (87.96 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.0368 mL	35.1840 mL	70.3680 mL
5 mM	1.4074 mL	7.0368 mL	14.0736 mL
10 mM	0.7037 mL	3.5184 mL	7.0368 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Select Batch:

Data Sheet (272 KB) SDS (394 KB)

COA (245 KB) HNMR (233 KB)

Handling Instructions (2659 KB)

References

[1]. Cooper AJ, et al. On the chemistry and biochemistry of 3-mercaptopyruvic acid, the alpha-keto acid analog of cysteine. J Biol Chem. 1982 Jan 25;257(2):816-26. PMID: 7054184. [Content Brief]

[2]. TANABE S, et al. Preparation of a sulfurtransferase substrate, sodium 3-mercaptopyruvate, from 3-bromopyruvic acid and sodium hydrosulfide[J]. Chemical and pharmaceutical bulletin, 1989, 37(10): 2843-2845.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	7.0368 mL	35.1840 mL	70.3680 mL	175.9201 mL
	5 mM	1.4074 mL	7.0368 mL	14.0736 mL	35.1840 mL
	10 mM	0.7037 mL	3.5184 mL	7.0368 mL	17.5920 mL
	15 mM	0.4691 mL	2.3456 mL	4.6912 mL	11.7280 mL
	20 mM	0.3518 mL	1.7592 mL	3.5184 mL	8.7960 mL
	25 mM	0.2815 mL	1.4074 mL	2.8147 mL	7.0368 mL
	30 mM	0.2346 mL	1.1728 mL	2.3456 mL	5.8640 mL
	40 mM	0.1759 mL	0.8796 mL	1.7592 mL	4.3980 mL
	50 mM	0.1407 mL	0.7037 mL	1.4074 mL	3.5184 mL
	60 mM	0.1173 mL	0.5864 mL	1.1728 mL	2.9320 mL
	80 mM	0.0880 mL	0.4398 mL	0.8796 mL	2.1990 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.