Sodium mercaptopyruvate
Based on 1 Customer Validation
Sodium mercaptopyruvate serves as a substrate for Lactate dehydrogenase and Sulfurtransferase. Sodium mercaptopyruvate forms through enzymatic transamination and oxidative deamination of L-cysteine (HY-Y0337). Sodium mercaptopyruvate abolishes lactate dehydrogenase reaction activity. It increases urinary thiosulfate excretion, fails to sustain rat growth by replacing L-cystine (HY-N0394), and does not induce morbidity or mortality in mice. Sodium mercaptopyruvate is applicable to research related to 3-mercaptopyruvate disulfiduria and 3-mercaptolactate disulfiduria.
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 10255-67-1
- Formula: C3H3NaO3S
- Molecular Weight:142.11
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Sodium mercaptopyruvate serves as an excellent substrate for bovine heart lactate dehydrogenase, and supports rapid stoichiometric NADH oxidation within 5 min[1].
Sodium mercaptopyruvate (5-10 mM; up to 4 h) loses lactate dehydrogenase reaction activity over time under neutral pH conditions: at pH 7.0 and 25°C, 50% of its activity is lost at approximately 80 minutes, and its stability increases at lower pH values[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male mice (23-25 g body weight)[1]
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Dosage:7 μmol/g body weight; 100 mM (72-hour incubated form)
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Administration:Injection; single dose
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Result:Showed no morbidity or mortality in four mice over a 48-hour observation period.
Showed no morbidity or mortality in eight male mice over the observation period when injected with the 72-hour incubated 100 mM form.
Chemical Information
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CAS No. 10255-67-1
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Appearance Solid
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Molecular Weight 142.11
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Formula C3H3NaO3S
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Color White to light yellow
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SMILES
O=C(C(CS)=O)O[Na]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
H2O : ≥ 4.17 mg/mL (29.34 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.0368 mL | 35.1840 mL | 70.3680 mL | 175.9201 mL |
| 5 mM | 1.4074 mL | 7.0368 mL | 14.0736 mL | 35.1840 mL | |
| 10 mM | 0.7037 mL | 3.5184 mL | 7.0368 mL | 17.5920 mL | |
| 15 mM | 0.4691 mL | 2.3456 mL | 4.6912 mL | 11.7280 mL | |
| 20 mM | 0.3518 mL | 1.7592 mL | 3.5184 mL | 8.7960 mL | |
| 25 mM | 0.2815 mL | 1.4074 mL | 2.8147 mL | 7.0368 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sodium mercaptopyruvate Related Classifications
HY-W170255 Related Classifications
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- Sodium mercaptopyruvate
- 10255-67-1
- Lactate Dehydrogenase
- Drug Derivative
- tRNA sulfurtransferase
- 3-mercaptopyruvate desulfurase
- rat
- 3-mercaptolactate disulfiduria
- 3-mercaptopyruvate disulfiduria
- L-cysteine
- mice
- lactate dehydrogenase
- glutamine transaminase
- 3-mercaptopyruvate sulfurtransferase
- Inhibitor
- inhibitor
- inhibit