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Cat. No.: HY-182446

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SRI-22818

SRI-22818 is a NF-κB activator with an EC₅₀ of 0.5 μM. SRI-22818 upregulates the expression of NF-κB and promotes its activation. SRI-22818 increases the level of SOD2. SRI-22818 exhibits activity in the SOD1^G93Amodel of amyotrophic lateral sclerosis (ALS). SRI-22818 can be used for research related to amyotrophic lateral sclerosis.

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CAS No.: 1429221-68-0
화학식: C₁₆H₁₂BrNO₃
분자량:346.18

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SRI-22818 Chemical Structure

CAS No.: 1429221-68-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Biological Activity

제품 설명

All NF-κB Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
SH-SY5Y	EC₅₀	0.5 μM Compound: Example 1	Activation of NF-KappaB (unknown origin) expressed in SH-SY5Y cells co-transfected with pNFkappaB-Luc plasmid measured after 24 hrs by Bright-Glo luciferase assay Activation of NF-KappaB (unknown origin) expressed in SH-SY5Y cells co-transfected with pNFkappaB-Luc plasmid measured after 24 hrs by Bright-Glo luciferase assay	[PMID: 31857831]

In Vitro

SRI-22818 increases the expression and activation of NF-κB as well as the level of SOD2 in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1429221-68-0
분자량 346.18
화학식 C₁₆H₁₂BrNO₃
SMILES

BrC(C=CC=C1)=C1N/C=C\C(C2=CC=C(OCO3)C3=C2)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Mathew B, et al. Development of novel small molecules for the treatment of ALS. Bioorg Med Chem Lett. 2020;30(4):126950. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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SRI-22818

All NF-κB Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SRI-22818 Related Classifications

HY-182446 Related Classifications