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Cat. No.: HY-161568

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TEAD-IN-10

TEAD-IN-10 (compound 15) has good selective activity and inhibitory effect on TEAD1 (IC₅₀=14 nM), TEAD2 (IC₅₀=179 nM) and TEAD3 (IC₅₀=4 nnM) as a covalent inhibitor. TEAD-IN-10 can be used for cancer research.

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CAS No.: 3032196-65-6
화학식: C₁₅H₁₄F₃NO
분자량:281.27

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

TEAD-IN-10 Chemical Structure

CAS No.: 3032196-65-6

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocol (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

TAED1

14 nM (IC₅₀)

TAED2

179 nM (IC₅₀)

TAED3

4 nM (IC₅₀)

All YAP Isoforms :

In Vitro

TEAD-IN-10 has a great inhibition for MCF-7 reporter assay (IC₅₀≤10 nM)^[1].
TEAD-IN-10 has a great selectivity for TEAD1 and TEAD2 with 97% and 98% inhibition in HEK293T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Cell Viability Assay^[1]

View Protocol

Cell Line:

NCl-H226 and H2052 cell lines
Concentration:
Incubation Time:

6 days
Result:

The inhibitory effect of H2052 cell line (IC₅₀≤100 nM) was better than that of NCl-H226 cell line (IC₅₀:100-500 nM).

Cell Proliferation Assay^[1]

View Protocol

Cell Line:

NCl-H226 and H2052 cell lines
Concentration:
Incubation Time:

7 days
Result:

The inhibition rate of anti-proliferation of both cell lines was greater than 75%.

Chemical Information

CAS No. 3032196-65-6
분자량 281.27
화학식 C₁₅H₁₄F₃NO
SMILES

O=C(C=C)N(C1)CC1/C=C/C2=CC=C(C(F)(F)F)C=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Henry William, et al. Yap/taz-tead oncoproteins inhibitors.WO2024059317A1.2023-09-15

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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