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Cat. No.: HY-19565

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KW-2450 tosylate

KW-2450 tosylate is an orally active Aurora A and B kinases, IGF-1R, and IR tyrosine kinases inhibitor. KW-2450 tosylate induces Apoptosis. KW-2450 tosylate also exhibits anticancer activity against triple-negative breast cancer.

For research use only. We do not sell to patients.

CAS No.: 1360433-93-7
Formula: C₃₅H₃₇N₅O₆S₂
Molecular Weight:687.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

KW-2450 tosylate Chemical Structure

CAS No.: 1360433-93-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Aurora Kinase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-468	IC₅₀	0.215 μM Compound: 99; KW-2450	Inhibition of human Aurora A kinase expressed in MDA-MB-468 cells Inhibition of human Aurora A kinase expressed in MDA-MB-468 cells	[PMID: 33650861]

Chemical Information

CAS No. 1360433-93-7
Molecular Weight 687.83
Formula C₃₅H₃₇N₅O₆S₂
SMILES

OCC(N(CC1)CCN1CC2=CC(NC(C3=C(C)C=CS3)=O)=C(/C=C/C4=NNC5=C4C=CC=C5)C=C2)=O.CC6=CC=C(S(=O)(O)=O)C=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kai K, et al. Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases. Mol Cancer Ther. 2015 Dec;14(12):2687-99. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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KW-2450 tosylate

All Aurora Kinase Isoforms