2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Labetuzumab govitecan

Labetuzumab govitecan  (Synonyms: IMMU 130; hMN-14-SN-38)

Cat. No.: HY-P99681

Labetuzumab govitecan (IMMU 130) is an Anti-CEACAM5/SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer.

For research use only. We do not sell to patients.

Labetuzumab govitecan Chemical Structure

Labetuzumab govitecan Chemical Structure

CAS No. : 1469876-18-3

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Description

Labetuzumab govitecan (IMMU 130) is an Anti-CEACAM5/SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer[1][2][3].

In Vivo

Labetuzumab govitecan (total of 1.0 mg, i.p.) prolongs median survival of GW-39 lung metastatic mouse model[2].
Labetuzumab govitecan (25 mg/kg, i.p., twice weekly for 4 weeks) prolongs median survival of sc LS174T Xenograft in nude mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: sc LS174T Xenograft in nude mice
Dosage: 25 mg/kg
Administration: i.p. twice weekly for 4 weeks
Result: Prolonged median survival.
Animal Model: LS174T tumor xenograft model in nude mice (PK assay)
Dosage: 0.25 mg
Administration: i.v.
Result: T1/2: 112.5 h; Cmax: 115 μg/mL; MRT: 147 h.
CAS No.
SMILES

[Labetuzumab govitecan]
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Labetuzumab govitecan1469876-18-3IMMU 130 hMN-14-SN-38IMMU130IMMU-130Antibody-Drug Conjugates (ADCs)Antibody-Drug ConjugatesCancerGW-39LS174Tcolorectal cancerSN-38Inhibitorinhibitorinhibit

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