2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Labetuzumab govitecan

Labetuzumab govitecan  (Synonyms: IMMU 130; hMN-14-SN-38)

Cat. No.: HY-P99681 Purity: 98.33%
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Labetuzumab govitecan (IMMU 130) is an Anti-CEACAM5/SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer.

For research use only. We do not sell to patients.

Labetuzumab govitecan Chemical Structure

Labetuzumab govitecan Chemical Structure

CAS No. : 1469876-18-3

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Based on 1 publication(s) in Google Scholar

Labetuzumab govitecan Related Antibodies

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Description

Labetuzumab govitecan (IMMU 130) is an Anti-CEACAM5/SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer[1][2][3].

In Vivo

Labetuzumab govitecan (total of 1.0 mg, i.p.) prolongs median survival of GW-39 lung metastatic mouse model[2].
Labetuzumab govitecan (25 mg/kg, i.p., twice weekly for 4 weeks) prolongs median survival of sc LS174T Xenograft in nude mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: sc LS174T Xenograft in nude mice
Dosage: 25 mg/kg
Administration: i.p. twice weekly for 4 weeks
Result: Prolonged median survival.
Animal Model: LS174T tumor xenograft model in nude mice (PK assay)
Dosage: 0.25 mg
Administration: i.v.
Result: T1/2: 112.5 h; Cmax: 115 μg/mL; MRT: 147 h.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Labetuzumab govitecan]
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light
Purity & Documentation

Purity: 98.33%

COA (291 KB) RP-HPLC (477 KB)

Handling Instructions (2659 KB)
References
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Labetuzumab govitecan Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Labetuzumab govitecan1469876-18-3IMMU 130 hMN-14-SN-38IMMU130IMMU-130Antibody-Drug Conjugates (ADCs)Antibody-Drug ConjugatesCancerGW-39LS174Tcolorectal cancerSN-38Inhibitorinhibitorinhibit

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