1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. LP 12 hydrochloride hydrate

LP 12 hydrochloride hydrate 

Cat. No.: HY-103105A
Handling Instructions

LP 12 hydrochloride hydrate is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride hydrate displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively).

For research use only. We do not sell to patients.

LP 12 hydrochloride hydrate Chemical Structure

LP 12 hydrochloride hydrate Chemical Structure

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Description

LP 12 hydrochloride hydrate is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride hydrate displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively)[1][2].

In Vitro

LP 12 hydrochloride hydrate (0.13 nM; spermatozoa) increases the percentage of hyperactivated spermatozoa. LP 12 hydrochloride hydrate do not affect straight-line velocity (VSL), curvilinear velocity (VCL), average-path velocity (VAP), linearity (LIN), straightness (STR), wobbler coefficient (WOB), amplitude of lateral head displacement (ALH), and beat-cross frequency (BCF)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Formula

C32H39N3O.HCl.xH2O

SMILES

O=C(NC1CCCC2=C1C=CC=C2)CCCCCN3CCN(C4=CC=CC=C4C5=CC=CC=C5)CC3.[H]Cl.[x].O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Product Name:
LP 12 hydrochloride hydrate
Cat. No.:
HY-103105A
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