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Cat. No.: HY-118370

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MF-592

MF-592 is an inhibitor of PGE2 (IC50=3 nM) and exhibits good oral PK properties in rats and dogs.

For research use only. We do not sell to patients.

CAS No.: 1064195-48-7
Formula: C₃₄H₃₃Cl₂N₃O₆S
Molecular Weight:682.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

MF-592 Chemical Structure

CAS No.: 1064195-48-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

MF-592 is an inhibitor of PGE2 (IC50=3 nM) and exhibits good oral PK properties in rats and dogs.

All Prostaglandin Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	14 nM Compound: 2f, MF-592	Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum	[PMID: 21215624]
HEK293	IC₅₀	3 nM Compound: 2; MF-592	Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay	[PMID: 26764191]
HEK293	IC₅₀	3 nM Compound: 2f, MF-592	Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting	[PMID: 21215624]

Chemical Information

CAS No. 1064195-48-7
Molecular Weight 682.61
Formula C₃₄H₃₃Cl₂N₃O₆S
SMILES

O=S(C1=C(C=CC=C1Cl)Cl)(NC(NC2(CC2)CC3=CC=C(C(C)=C3)N(C4=O)CC5=C4C(OCC)=C6C=CC=CC6=C5OCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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