MK-761 free base
Based on 1 Customer Validation
MK-761 free base is an orally effective β2-adrenergic receptor antagonist. MK-761 free base attenuates positive inotropic effects, reduces arterial pressure, enhances the contractility of papillary muscles in cat hearts, and exerts effects mediated by catecholamine release. MK-761 free base can be used in the research of hypertension.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.56%
- CAS No.: 65321-41-7
- Formule: C13H19N3O2
- Masse moléculaire:249.31
-
Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform Adrenergic Receptor
More
Activité biologique
Description
IC50 & Target
[1]|
Beta-2 adrenergic receptor |
In Vitro
MK-761 (0.125-2.0 μg/mL; 30 min) free base enhances the contractility of isolated cat papillary muscles in a dose-dependent manner, and this positive inotropic effect is significantly inhibited by pretreatment with Timolol (HY-17494)[1].
MK-761 (0.03-1.0 μg/mL; 30 min) free base blocks the positive inotropic effect of isoprenaline (HY-B0468) on isolated cat papillary muscles[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Wistar-Okamoto spontaneously hypertensive (SH) (male, 30-40 weeks, 290-350 g)[1]
-
Dosage:1.25 mg/kg (no pretreatment); 0.312 mg/kg (Timolol pretreatment)
-
Administration:p.o.; single dose
-
Result:Lowered mean arterial pressure in SH rats, with maximal effect reached at 1 hour after administration of 1.25 mg/kg p.o.
Showed no significant difference in heart rate changes compared to vehicle control.
Exhibited an antihypertensive effect at 0.312 mg/kg p.o. that was not antagonized by pretreatment with 8 mg/kg p.o. timolol.
Had a relative antihypertensive potency of 3.4 (relative to hydralazine, potency = 1) with 95% confidence limits of 1.8 and 7.3.
Chemical Information
-
CAS No. 65321-41-7
-
Appearance Solid
-
Masse moléculaire 249.31
-
Formule C13H19N3O2
-
Color Off-white to light yellow
-
SMILES
N#CC1=CC=CN=C1OC[C@H](CNC(C)(C)C)O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (401.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
-
Fiche technique (273 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0111 mL | 20.0554 mL | 40.1107 mL | 100.2768 mL |
| 5 mM | 0.8022 mL | 4.0111 mL | 8.0221 mL | 20.0554 mL | |
| 10 mM | 0.4011 mL | 2.0055 mL | 4.0111 mL | 10.0277 mL | |
| 15 mM | 0.2674 mL | 1.3370 mL | 2.6740 mL | 6.6851 mL | |
| 20 mM | 0.2006 mL | 1.0028 mL | 2.0055 mL | 5.0138 mL | |
| 25 mM | 0.1604 mL | 0.8022 mL | 1.6044 mL | 4.0111 mL | |
| 30 mM | 0.1337 mL | 0.6685 mL | 1.3370 mL | 3.3426 mL | |
| 40 mM | 0.1003 mL | 0.5014 mL | 1.0028 mL | 2.5069 mL | |
| 50 mM | 0.0802 mL | 0.4011 mL | 0.8022 mL | 2.0055 mL | |
| 60 mM | 0.0669 mL | 0.3343 mL | 0.6685 mL | 1.6713 mL | |
| 80 mM | 0.0501 mL | 0.2507 mL | 0.5014 mL | 1.2535 mL | |
| 100 mM | 0.0401 mL | 0.2006 mL | 0.4011 mL | 1.0028 mL |
MK-761 free base Related Classifications
HY-123449 Related Classifications
Powered by Bioz