Antcin A
Based on 1 Customer Validation
Antcin A is an orally active modulator of p53 and glucocorticoid receptor (GR), with an IC50 of 8.55 μM against human GR. Through transcriptional activation of p53, Antcin A induces miR-200c and inhibits ZEB1, regulates epithelial-mesenchymal transition markers, and suppresses cancer cell migration/invasion. Antcin A activates GR, inhibits Na+/K+-ATPase and NLRP3 inflammasome assembly, pyroptosis (pyroptosis) and pro-inflammatory cytokine release, reduces hepatic lipid deposition, improves liver function, and reverses metabolic changes induced by the SARS-CoV-2 spike protein. Antcin A can be used in research related to breast cancer, head and neck cancer, non-alcoholic fatty liver disease, and coronavirus disease 2019 (COVID-19).
For research use only. We do not sell to patients.
- Purity: 99.71%
- CAS No.: 163597-24-8
- Formula: C29H42O4
- Molecular Weight:454.64
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[4]|
NLRP3 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KB | IC50 |
179.6 μM
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Cytotoxicity against human head and neck cancer KB cells, quantified as reduction of 50% cell survival.
Cytotoxicity against human head and neck cancer KB cells, quantified as reduction of 50% cell survival.
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31883608 |
| Neutrophil | IC50 |
8.55 μM
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Inhibition of fMLP-induced superoxide generation in cultured human peripheral neutrophils.
Inhibition of fMLP-induced superoxide generation in cultured human peripheral neutrophils.
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31883608 |
In Vitro
Antcin A (87.6-188.1 μM) selectively reduces cell survival in human TSCCa, GNM, and KB head and neck cancer cell lines with IC50 of 188.1 μM, 87.6 μM, and 179.6 μM, respectively[2].
Antcin A (0.1-10 μM; 1 h) induces glucocorticoid receptor nuclear translocation in human lung cancer A549 cells, with a minimal effective concentration of 10 μM for 1 h incubation[3].
Antcin A inhibits fMLP-induced superoxide generation in human peripheral neutrophils with an IC50 of 8.55 μM, exhibiting greater potency than ibuprofen[2].
Antcin A induces glucocorticoid receptor activation in human lung A549 cells, exerting an anti-inflammatory effect comparable to synthetic glucocorticoids via high-affinity binding to GR[2].
Antcin A (5-15 mg/L; 6 h pre-incubation, 12 h LPS/Nigericin treatment) dose-dependently inhibits pyroptosis and NLRP3 inflammasome activation in mouse liver Kupffer cells, reducing inflammatory factor secretion, membrane permeability, and cleavage of GSDMD-FL[4].
Antcin A (15 mg/L; 6-48 h) is non-toxic to mouse liver Kupffer cells, with no effect on cell viability or apoptosis over a 48-hour incubation period[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Kupffer cells
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Concentration:15 mg/L
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Incubation Time:6, 12, 24, 48 h
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Result:Showed no effect on cell apoptosis over a 48-hour incubation period.
In Vivo
Antcin A (10 mg/kg) does not cause observable physiological changes or mortality in mice[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J wild-type mice[4]
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Dosage:5, 10 μg/mL
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Administration:p.o.; once daily for 28 days
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Result:Reduced hepatic lipid accumulation in a dose-dependent manner, with the high-dose group showing a more pronounced effect.
Attenuated liver tissue inflammation, reduced bubble-like structural changes, and lowered serum levels of ALT and AST.
Decreased the levels of inflammatory factors IL-1β, IL-18, and TNF-α in both peripheral blood and liver tissue.
Inhibited activation of the NLRP3 inflammasome, downregulated protein expression of NLRP3 and Caspase-1, and suppressed cleavage of GSDMD-FL to GSDMD-NT in liver tissue, with the high-dose group showing greater inhibition.
Chemical Information
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CAS No. 163597-24-8
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Appearance Solid
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Molecular Weight 454.64
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Formula C29H42O4
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Color Off-white to light yellow
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SMILES
C[C@@]12C3=C(CC[C@@]1([H])[C@@H](C(CC2)=O)C)[C@@]4([H])[C@](CC3=O)([C@@](CC4)([H])[C@H](C)CCC(C(C)C(O)=O)=C)C
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Structure Classification
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Initial Source
Antrodia cinnamomea
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (285 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antcin A Related Classifications
HY-N9921 Related Classifications
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