Octyl-α-ketoglutarate (Synonyms: 1-Octyl 2-oxopentanedioate)

Cat. No.: HY-114333 Pureza: 99.9%: Ficha de datos
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Octyl-α-ketoglutarate (1-Octyl 2-oxopentanedioate) is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional tricarboxylic acid (TCA) cycle, stimulating prolyl hydroxylase (PHD) activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD.

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Octyl-α-ketoglutarate Estructura química

No. CAS : 876150-14-0

Tamaño	Stock	Cantidad
Solvent
1 mg (38.71 mM * 100 μL in Methyl acetate)	En stock	Estimated Time of Arrival: December 31
Solvent
5 mg (38.71 mM * 500 μL in Methyl acetate)	En stock	Estimated Time of Arrival: December 31

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Descripciòn	Octyl-α-ketoglutarate (1-Octyl 2-oxopentanedioate) is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional tricarboxylic acid (TCA) cycle, stimulating prolyl hydroxylase (PHD) activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD^[1].
Peso molecular	258.31
Fòrmula	C₁₃H₂₂O₅
No. CAS	876150-14-0
Appearance	Liquid
Color	Colorless to light yellow
SMILES	O=C(OCCCCCCCC)C(CCC(O)=O)=O
Envío	Room temperature in continental US; may vary elsewhere.
Almacenamiento	Solution, -20°C, 2 years
Pureza y Documentación	Purity: 99.9% Select Batch: Ficha de datos (262 KB) SDS (394 KB) COA (240 KB) Instrucciones de manejo (2659 KB)
Referencias	[1]. MacKenzie ED, et al. Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol Cell Biol. 2007 May;27(9):3282-9. [Content Brief]

Octyl-α-ketoglutarate Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Octyl-α-ketoglutarate876150-14-01-Octyl 2-oxopentanedioateHIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHα-ketoglutarateHEK293 cellsTCA cyclePHDInhibitorinhibitorinhibit

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Octyl-α-ketoglutarate (Synonyms: 1-Octyl 2-oxopentanedioate)

Octyl-α-ketoglutarate Related Antibodies

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas HIF/HIF Prolyl-Hydroxylase:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Octyl-α-ketoglutarate Related Classifications

Calculadora de molaridad

Calculadora de dilución